E
Eva María Galán-Moya
Researcher at University of Castilla–La Mancha
Publications - 41
Citations - 1033
Eva María Galán-Moya is an academic researcher from University of Castilla–La Mancha. The author has contributed to research in topics: Cancer & Triple-negative breast cancer. The author has an hindex of 15, co-authored 38 publications receiving 788 citations. Previous affiliations of Eva María Galán-Moya include Centre national de la recherche scientifique & Paris Descartes University.
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Journal ArticleDOI
Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway
Eva María Galán-Moya,Eva María Galán-Moya,Eva María Galán-Moya,Armelle Le Guelte,Armelle Le Guelte,Armelle Le Guelte,Evelyne Lima-Fernandes,Evelyne Lima-Fernandes,Evelyne Lima-Fernandes,Cécile Thirant,Cécile Thirant,Julie Dwyer,Julie Dwyer,Julie Dwyer,Nicolas Bidère,Pierre-Olivier Couraud,Pierre-Olivier Couraud,Pierre-Olivier Couraud,Mark G.H. Scott,Mark G.H. Scott,Mark G.H. Scott,Marie-Pierre Junier,Marie-Pierre Junier,Hervé Chneiweiss,Hervé Chneiweiss,Julie Gavard,Julie Gavard,Julie Gavard +27 more
TL;DR: It is shown that factors emanating from brain endothelial cells positively control the expansion of long‐term glioblastoma stem‐like cells and that both pharmacological inhibition of and RNA interference with the mammalian target of rapamycin (mTOR) pathway reduce their spheroid growth.
Journal ArticleDOI
P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance.
M A de la Cruz-Morcillo,María Llanos Valero,Juan Luis Callejas-Valera,Laura Arias-González,Pedro Melgar-Rojas,Eva María Galán-Moya,Elena Garcia-Gil,Jesús García-Cano,Ricardo Sánchez-Prieto +8 more
TL;DR: A critical role is demonstrated for the p38MAPK signaling pathway in the cellular response to 5-FU by controlling the balance between apoptosis and autophagy.
Journal ArticleDOI
Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma
Lucas Treps,Sébastien Edmond,Elizabeth Harford-Wright,Eva María Galán-Moya,Eva María Galán-Moya,Eva María Galán-Moya,Alain Schmitt,Alain Schmitt,Alain Schmitt,Sandy Azzi,Sandy Azzi,Sandy Azzi,A Citerne,A Citerne,A Citerne,Nicolas Bidère,Damien Ricard,Julie Gavard +17 more
TL;DR: It is reported that extracellular vesicles released by patient-derived glioblastoma cells disrupt the endothelial barrier and suggested that EV-delivered Sema3A orchestrates loss of barrier integrity in gliOBlastoma and may be of interest for prognostic purposes.
Journal ArticleDOI
Glioblastoma Cell-Secreted Interleukin-8 Induces Brain Endothelial Cell Permeability via CXCR2
Julie Dwyer,Julie Dwyer,Julie Dwyer,Jagoda K. Hebda,Jagoda K. Hebda,Jagoda K. Hebda,Armelle Le Guelte,Armelle Le Guelte,Armelle Le Guelte,Eva María Galán-Moya,Eva María Galán-Moya,Eva María Galán-Moya,Sherri S. Smith,Sherri S. Smith,Sherri S. Smith,Sandy Azzi,Sandy Azzi,Sandy Azzi,Nicolas Bidère,Julie Gavard,Julie Gavard,Julie Gavard +21 more
TL;DR: Evidence is presented that the glioblastoma secretome provides pro-angiogenic signals sufficient to disrupt VE-cadherin-mediated cell-cell junctions and promote endothelial permeability in brain microvascular endothelial cells.
Journal ArticleDOI
Differential Proteomic Analysis of Human Glioblastoma and Neural Stem Cells Reveals HDGF as a Novel Angiogenic Secreted Factor
Cécile Thirant,Eva María Galán-Moya,Luiz Gustavo Dubois,Sébastien Pinte,Philippe Chafey,Cédric Broussard,Pascale Varlet,Bertrand Devaux,Fabrice Soncin,Julie Gavard,Marie-Pierre Junier,Hervé Chneiweiss +11 more
TL;DR: The results identify a novel candidate, by which GSCs can support neoangiogenesis, a high‐grade glioma hallmark, and illustrates the usefulness of comparative proteomic analysis to decipher molecular pathways, which underlie GSC properties.