Eva Tomas

TL;DR: Both in vivo and in vitro, activation of AMPK was the first effect of gACRP30 and was transient, whereas alterations in malonyl CoA and ACC occurred later and were more sustained, indicating that gAC RP30 most likely exerts its actions on muscle fatty acid oxidation by inactivating ACC via activation ofAMPK and perhaps other signal transduction proteins.

TL;DR: Adiponectin is an important contributor to PPARγ-mediated improvements in glucose tolerance through mechanisms that involve the activation of the AMPK pathway.

TL;DR: T trimeric and HMW/hexameric Acrp30 activate different signal transduction pathways, and Acr p30 represents a novel example of the control of ligand signaling via changes in its oligomerization state.

TL;DR: A single dose of AICAR leads to an apparent enhancement in whole-body, muscle, and liver insulin action in HF rats that extends beyond the expected time of AM PK activation, and the results suggest that pharmacological activation of AMPK may have potential in treating insulin-resistant states and type 2 diabetes.

TL;DR: The results indicate that TZDs can act within minutes to activate AMPK in mammalian tissues and suggest that this effect is associated with a change in cellular energy state and that it is not dependent on PPARgamma-mediated gene transcription.