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Evan C. Lam
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 34
Citations - 3682
Evan C. Lam is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 9, co-authored 22 publications receiving 929 citations. Previous affiliations of Evan C. Lam include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Wilfredo F. Garcia-Beltran,Wilfredo F. Garcia-Beltran,Evan C. Lam,Kerri St. Denis,Adam Nitido,Zeidy H. Garcia,Blake M. Hauser,Jared Feldman,Maia N. Pavlovic,David Gregory,Mark C. Poznansky,Alex Sigal,Alex Sigal,Aaron G. Schmidt,A. John Iafrate,Vivek Naranbhai,Vivek Naranbhai,Alejandro B. Balazs +17 more
TL;DR: In this article, the authors evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2.
Journal ArticleDOI
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
Wilfredo F. Garcia-Beltran,K. S. St. Denis,Angelique Hoelzemer,Evan C. Lam,Adam Nitido,M. Sheehan,Cristhian Berríos,Onosereme Ofoman,Christina C. Chang,Blake M. Hauser,Jared Feldman,Alex Roederer,David Gregory,Mark C. Poznansky,Aaron G. Schmidt,A. John Iafrate,Vivek Naranbhai,Alejandro B. Balazs +17 more
TL;DR: In this article , the authors measured the neutralization potency of sera from 88 mRNA-1273, 111 BNT162b, and 40 Ad26.1.1/B.COV2.
Journal ArticleDOI
COVID-19-neutralizing antibodies predict disease severity and survival.
Wilfredo F. Garcia-Beltran,Evan C. Lam,Michael G Astudillo,Diane Yang,Tyler E. Miller,Jared Feldman,Blake M. Hauser,Timothy M. Caradonna,Kiera L. Clayton,Adam Nitido,Mandakolathur R. Murali,Galit Alter,Richelle C. Charles,Anand S. Dighe,John A. Branda,Jochen K. Lennerz,Daniel Lingwood,Aaron G. Schmidt,A. John Iafrate,Alejandro B. Balazs +19 more
TL;DR: It is found that severe cases resulting in intubation or death exhibited increased inflammatory markers, lymphopenia, pro-inflammatory cytokines, and high anti-receptor binding domain (RBD) antibody levels, highlighting the importance of neutralizing humoral immunity on disease progression and the need to develop broadly protective interventions to prevent future coronavirus pandemics.
Posted ContentDOI
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
Wilfredo F. Garcia-Beltran,Wilfredo F. Garcia-Beltran,Evan C. Lam,Kerri St. Denis,Adam Nitido,Zeidy H. Garcia,Blake M. Hauser,Jared Feldman,Maia N. Pavlovic,David Gregory,Mark C. Poznansky,Alex Sigal,Alex Sigal,Aaron G. Schmidt,A. John Iafrate,Vivek Naranbhai,Alejandro B. Balazs +16 more
TL;DR: In this article, the authors evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against 10 globally circulating strains of SARS-CoV-2.
Journal ArticleDOI
T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals
Vivek Naranbhai,Anusha Nathan,C. Kaseke,Cristhian Berríos,Ashok Khatri,Shawn Choi,Matthew A. Getz,Rhoda Tano-Menka,Onosereme Ofoman,Alton C. Gayton,Fernando Senjobe,Zezhou Zhao,K. S. St. Denis,Evan C. Lam,Mary Carrington,Wilfredo F. Garcia-Beltran,Alejandro B. Balazs,Bruce D. Walker,A. John Iafrate,Gaurav D. Gaiha +19 more
TL;DR: In this article , the authors show that T cell responses in individuals with prior infection, vaccination, both prior infection and vaccination, and boosted vaccination are largely preserved to Omicron spike and non-spike proteins.