E
Ewan K.A. Millar
Researcher at St George's Hospital
Publications - 82
Citations - 4280
Ewan K.A. Millar is an academic researcher from St George's Hospital. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 34, co-authored 75 publications receiving 3438 citations. Previous affiliations of Ewan K.A. Millar include St. Vincent's Health System & University of Sydney.
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Journal ArticleDOI
Prediction of Local Recurrence, Distant Metastases, and Death After Breast-Conserving Therapy in Early-Stage Invasive Breast Cancer Using a Five-Biomarker Panel
Ewan K.A. Millar,Peter Graham,Sandra A O'Toole,Catriona M. McNeil,Lois Browne,Adrienne Morey,Sarah A. Eggleton,Julia Beretov,Con Theocharous,Anne Capp,Elias H. Nasser,John H. Kearsley,Geoffrey P Delaney,George Papadatos,C Fox,Robert L. Sutherland +15 more
TL;DR: Although this approach provides additional information to predict time to IBTR, LRR, DDFS, and death from breast cancer, its predictive power is less than that of traditional pathologic indices.
Journal ArticleDOI
A single-cell and spatially resolved atlas of human breast cancers.
Sunny Z. Wu,Sunny Z. Wu,Ghamdan Al-Eryani,Ghamdan Al-Eryani,Daniel L. Roden,Daniel L. Roden,Simon Junankar,Simon Junankar,Kate Harvey,Alma Andersson,Aatish Thennavan,Chenfei Wang,James R. Torpy,James R. Torpy,Nenad Bartonicek,Nenad Bartonicek,Taopeng Wang,Taopeng Wang,Ludvig Larsson,Dominik C. Kaczorowski,Neil I. Weisenfeld,Cedric Uytingco,Jennifer Chew,Zachary Bent,Chia-Ling Chan,Vikkitharan Gnanasambandapillai,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Laurence Gluch,Mun N. Hui,Jane Beith,Andrew Parker,Andrew Parker,Elizabeth Robbins,Davendra Segara,Caroline Cooper,Caroline Cooper,Cindy Mak,Belinda Chan,Sanjay Warrier,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Ewan K.A. Millar,Ewan K.A. Millar,Ewan K.A. Millar,Joseph E. Powell,Joseph E. Powell,Stephen R. Williams,X. Shirley Liu,Sandra A O'Toole,Elgene Lim,Elgene Lim,Elgene Lim,Joakim Lundeberg,Charles M. Perou,Alexander Swarbrick,Alexander Swarbrick +57 more
TL;DR: In this paper, a single-cell and spatially resolved transcriptomics analysis of human breast cancers is presented, which reveals recurrent neoplastic cell heterogeneity and heterotypic interactions play central roles in disease progression.
Journal ArticleDOI
PI3K pathway activation in breast cancer is associated with the basal‐like phenotype and cancer‐specific mortality
Elena Lopez-Knowles,Sandra A O'Toole,Catriona M. McNeil,Catriona M. McNeil,Ewan K.A. Millar,Min Ru Qiu,Min Ru Qiu,Paul Crea,Roger J. Daly,Roger J. Daly,Elizabeth A. Musgrove,Elizabeth A. Musgrove,Robert L. Sutherland,Robert L. Sutherland +13 more
TL;DR: It is concluded that >70% of breast cancers have an alteration in at least 1 component of the PI3K pathway and this might be exploited to therapeutic advantage especially in “basal‐like” cancers.
Journal ArticleDOI
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
Clare G Fedele,Lisa M Ooms,Miriel Ho,Jessica L. Vieusseux,Sandra A O'Toole,Ewan K.A. Millar,Elena Lopez-Knowles,Absorn Sriratana,Rajendra Gurung,Laura Baglietto,Graham G. Giles,Charles G. Bailey,John E.J. Rasko,Benjamin J. Shields,John T. Price,Philip W. Majerus,Robert L. Sutherland,Tony Tiganis,Catriona McLean,Christina Anne Mitchell +19 more
TL;DR: Evidence is provided that INPP4B functions as a tumor suppressor by negatively regulating normal and malignant mammary epithelial cell proliferation through regulation of the PI3K/Akt signaling pathway, and that loss of IN PP4B protein is a marker of aggressive basal-like breast carcinomas.
Journal ArticleDOI
The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.
E Y Tan,M Yan,M Yan,Leticia Campo,Cheng Han,E Takano,E Takano,Helen Turley,I Candiloro,I Candiloro,Francesco Pezzella,K C Gatter,Ewan K.A. Millar,Ewan K.A. Millar,Sandra A O'Toole,Sandra A O'Toole,Catriona M. McNeil,Catriona M. McNeil,Paul Crea,Davendra Segara,Robert L. Sutherland,Adrian L. Harris,Stephen B. Fox,Stephen B. Fox +23 more
TL;DR: The association between basal phenotype and CAIX suggests that the more aggressive behaviour of these tumours is partly due to an enhanced hypoxic response and raises the possibility that targeted therapy against HIF pathway or downstream genes such as CAs may be an approach to investigate for these patients.