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F. Boran

Bio: F. Boran is an academic researcher from Hittite University. The author has contributed to research in topics: Self-healing hydrogels & Controlled release. The author has co-authored 1 publications.

Papers
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Journal ArticleDOI
F. Boran1
TL;DR: In this article, the swelling capacity and long-term stability of polyvinyl alcohol (PVA) hydrogels were determined as a function of time at pH 2.1, 5.5 and 7.4 and displayed controlled release for 120 h.
Abstract: The preparation of poly(vinyl alcohol) (PVA) hydrogels was succeeded via the freeze-thawing (F/T) method by varying the synthesis parameter conditions. The swelling capacity and long-term stability of the hydrogels were determined as a function of time at pH 2.1, 5.5 and 7.4 and found to be mainly affected by the synthesis parameter conditions. These studies showed that the swelling ratio generally increased with a low number of F/T cycles (2 and 3), high freezing temperature (− 5 and − 16 °C) and freeze-dried of drying type for all three pH mediums. The dried hydrogels at room temperature were found to be more stable hydrogels. In addition, the drug release studies of salicylic acid as a drug model were investigated at pH 7.4 and displayed controlled release for 120 h. The release kinetic studies obtained from drug release data demonstrated that the PVA hydrogel fits well into the Higuchi model. The release mechanism of PVA hydrogel was also determined as super case II type.

4 citations


Cited by
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Journal ArticleDOI
01 May 2022-Gels
TL;DR: The characteristics and crosslinking methods of natural and synthetic hydrogels are introduced and the design and principle of intelligent hydrogel used for drug release and tissue engineering are highlighted.
Abstract: Due to their good absorption, satisfactory biocompatibility, and high safety, hydrogels have been widely used in the field of biomedicine, including for drug delivery and tissue regeneration. In this review, we introduce the characteristics and crosslinking methods of natural and synthetic hydrogels. Then, we highlight the design and principle of intelligent hydrogels (i.e., responsive hydrogels) used for drug release. Moreover, we introduce the application of the application of hydrogels in drug release and tissue engineering, and the limitations and research directions of hydrogel in drug release and tissue engineering are also considered. We hope that this review can provide a reference for follow-up studies in related fields.

20 citations

Journal ArticleDOI
30 Jun 2022
TL;DR: In this article , a polyvinyl alcohol/sodium alginate (PVA/SA) hydrogel was successfully prepared by freeze thaw process without crosslinking agent.
Abstract: Polyvinyl alcohol/sodium alginate (PVA/SA) hydrogel was successfully prepared by freeze thaw process. Without crosslinking agent, hydrogel was formed by using 3, 5 and 7 consecutive cycles of freeze thaw. Hydrogel can be formed by hydrogen bonding formation between OH-group of sodium alginate and polyvinyl alcohol throughout network. Scanning electron microscope reported that microstructure of hydrogel was well packed. The interconnect porosity was also observed. Differential scanning calorimetry exhibited that two exothermic peaks at temperature of 110℃ and 225℃ were observed due to evaporation of water molecule and melting temperature of hydrogel, respectively. The swelling behavior was rapidly increased within initial stage and then it was dimensionally stable. With low sodium alginate content, tensile strength was slightly superior, whereas low in vitro degradation behavior was observed. It was remarkable to note that polyvinyl alcohol/sodium alginate (PVA/SA) hydrogel exhibited outstanding properties for being as a medical material.

2 citations

Journal ArticleDOI
TL;DR: In this paper , an interpenetrating double-network hydrogel (LMP/AA/PVAH) was prepared based on low methoxy pectin, acrylic acid (AA) and polyvinyl alcohol (PVA).

2 citations

Posted ContentDOI
16 Jun 2023
TL;DR: In this paper , the authors focused on the preparation and subsequent characterization of structural and transport properties of hydrogels with double-network concerning their application potential, and they were prepared as a combination of synthetic polymer and natural polysaccharide, such as polyvinyl alcohol (PVA) and sodium alginate (SA), where mass ratio of those polymers was 1:1.
Abstract: Abstract The presented paper is focused on preparation and subsequent characterization of structural and transport properties of hydrogels with double-network concerning their application potential. Hybrid hydrogels were prepared as a combination of synthetic polymer and natural polysaccharide, such as polyvinyl alcohol (PVA) and sodium alginate (SA), where mass ratio of those polymers was 1:1. In the preparation of the gel’s hybrid network a freeze-thawing cycle technique for physical cross-linking of PVA was used, also calcium ions were used for ionic cross-linking of sodium alginate. Lecithin as a modification of the internal structure of hybrid hydrogels was also used in gel’s system preparation. Physicochemical methods were used to characterise their viscoelastic, swelling and transport properties. Rheology measurements, specifically oscillation and amplitude tests, were used to study these mechanical properties. Morphology of the prepared hybrid hydrogels was confirmed by electron microscope scanning. Transport and release properties of gel systems were determined by diffusion experiments with the UV-VIS spectrometry detection method, in which an organic dye (methylene blue) was used as a model probe.