F. E. Bader

Bio: F. E. Bader is an academic researcher from Ciba Specialty Chemicals. The author has contributed to research in topics: Rauwolfia alkaloid & Yohimbine. The author has an hindex of 3, co-authored 3 publications receiving 47 citations.

Rauwolfia alkaloids. XI. Isolation of an isomer of yohimbine.

Abstract: Aus Ajmalin-Mutterlaugen vonRauwolfia serpentina Benth. ist ein weiteres Isomeres des Yohimbins isoliert worden. Das Alkaloid besitzt zwei verschiedene Kristallformen, wovon die hoher schmelzende in ihren Eigenschaften weitgehend dem Ajmalinin gleicht. Spektren und Derivate werden beschrieben.

The cholinergic receptor.

Abstract: SINCE the time when a knowledge of anatomical structure first offered a contribution to the understanding of the functioning of the living body, advances in physiology, and later in biochemistry, helped to further our understanding of the basic principles of life. This approach in biological research has remained the same in modern times. As we try to solve more and more problems of ultrastructural dimensions we still follow the same road that leads from morphology to function. Perhaps one day we will come to the point where we can see molecules and ions in action in a living tissue or organ. Then the two routes will meet and we will have complete understanding of a biological phenomenon. The final goal of all our endeavours in research will therefore be to link morphology with function. Today good tools have been developed with which to attack the basic problems of this sort. Microscopy has been surpassed by electron microscopy ; simple electrodes for measuring action potentials by microelectrodes, which can be placed inside single cells. Chemical compounds can be labelled with radioactive atoms and followed in the body to their site of action. Enzymes can be measured in single cells or even in microsomes. These are only a few of the many ingenious methods used in modern laboratories for biological research. In the instance I propose to discuss we have applied some of these methods to the elucidation of the nature of the cholinergic receptor.

Chemotaxonomy: A Tool for Plant Classification

Abstract: Nature which consists of so many variabilities of living components of the environment possesses useful, harmful and inactive chemical constituents. The classification based on these chemical constituents is known as chemotaxonomy. All the living components of the environment produce secondary metabolites that are derived from primary metabolites. The chemical structure of the secondary metabolites is often specific and restricted to taxonomically related organisms. The classification of plants on the basis of specific class of secondary metabolites and their biosynthetic pathways constitutes chemotaxonomy. Its study is helpful to taxonomist, phytochemists and pharmacologists to solve selected taxonomical problems

Melodinines M-U, cytotoxic alkaloids from Melodinus suaveolens.

Abstract: Nine new alkaloids, melodinines M-U (1-9), and 11 known alkaloids were isolated from Melodinus suaveolens. The new structures were elucidated by extensive NMR and mass spectroscopic analyses and comparison to known compounds. All compounds were evaluated for their cytotoxicity against five human cancer cell lines. Compounds 6, 11, and 16 showed significant cytotoxicity.

Monoterpenoid Indole Alkaloids from Alstonia yunnanensis

Abstract: Eight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of. the new alkaloids were established by means of extensive spectroscopic methods. Alstoyunines C (3), E (5), and F (6) showed selective inhibition of Cox-2 (>75%). Alstoyunine F (6) showed weak cytotoxicity against the human myeloid leukemia HL-60 (IC(50) = 3.89 mu M) and hepatocellular carcinoma SMMC-7721 (IC(50) = 21.73 mu M) cell lines.