F
F. R. Batchelor
Publications - 10
Citations - 474
F. R. Batchelor is an academic researcher. The author has contributed to research in topics: Penicillin & Hydrolysis. The author has an hindex of 9, co-authored 10 publications receiving 469 citations.
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Journal ArticleDOI
Bacteriological studies on a new penicillin—brl.1241
Journal ArticleDOI
Formation of 6-aminopenicillanic acid from penicillin by enzymatic hydrolysis.
G. N. Rolinson,F. R. Batchelor,D. Butterworth,J. Cameron-Wood,M. Cole,G. C. Eustace,Marian V. Hart,Mark Richards,E. B. Chain +8 more
TL;DR: It is found that enzymatic activity which brings about reaction (1) is fairly widespread among micro-organisms.
Journal ArticleDOI
6-Aminopenicillanic acid. III. Isolation and purification.
TL;DR: Crystalline 6-aminopenicillanic acid was obtained by concentration of this ion exchange eluate and pH adjustment to the point of minimum solubility and further purification could be achieved by chromatography on a column of cellulose before proceeding with the crystallization step.
Journal ArticleDOI
6-Aminopenicillanic acid VI. Formation of 6-aminopenicillanic acid from penicillin by enzymic hydrolysis
TL;DR: Penicillin amidase activity, resulting in the hydrolysis of phenoxymethylpenicillin to give 6-aminopenicillanic acid, was found to be widespread among micro-organisms and the pH optimum for enzyme activity in the direction of synthesis was 5.0 to 5.5.
Journal ArticleDOI
6-Aminopenicillanic acid. I. 6-Aminopenicillanic acid in penicillin fermentations.
TL;DR: A high aeration rate was necessary for efficient utilization of precursor for Penicillin formation and under such conditions, the presence of precursor resulted in an increase in the total amount of penicillin nucleus produced in the fermentation.