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Fabienne C. Fiesel

Researcher at Mayo Clinic

Publications -  50
Citations -  10948

Fabienne C. Fiesel is an academic researcher from Mayo Clinic. The author has contributed to research in topics: PINK1 & Parkin. The author has an hindex of 31, co-authored 44 publications receiving 9540 citations. Previous affiliations of Fabienne C. Fiesel include German Center for Neurodegenerative Diseases & University of Tübingen.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler, +6 more
- 24 Jan 2010 - 
TL;DR: Functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease, are provided.
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The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.

Sven Geisler, +7 more
- 01 Oct 2010 - 
TL;DR: It is shown that whole mitochondria are turned over via macroautophagy, and PD-associated PINK1 mutations abrogate autophagy of impaired mitochondria upstream of Parkin, which may contribute to disease pathogenesis.
Journal ArticleDOI

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

Fabienne C. Fiesel, +18 more
- 06 Jan 2010 - 
TL;DR: Loss of functional TDP‐43 causes HDAC6 downregulation and might thereby contribute to pathogenesis, andHDAC6‐dependent reduction of cellular aggregate formation and increased cytotoxicity of polyQ‐expanded ataxin‐3 were found in T DP‐43 silenced cells.
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TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity

Aaron Voigt, +9 more
- 18 Aug 2010 - 
TL;DR: Using a bi-systemic approach, this work uncovered a requirement of inherent TDP-43 RNA-binding function—but not ALS/FTLD-linked mutation, mislocalization, or truncation—for T DP-43-mediated neurotoxicity in vivo.