Author
Fabio Gosetti
Other affiliations: University of Milan, University of Milano-Bicocca
Bio: Fabio Gosetti is an academic researcher from University of Eastern Piedmont. The author has contributed to research in topics: Mass spectrometry & Analyte. The author has an hindex of 29, co-authored 94 publications receiving 2644 citations. Previous affiliations of Fabio Gosetti include University of Milan & University of Milano-Bicocca.
Papers published on a yearly basis
Papers
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TL;DR: The review discusses the pitfalls of the matrix effect in mass spectrometry detection hyphenated to liquid chromatography separation and proposes hypotheses to explain the observed behaviours and proposes methods and strategies to overcome the matrix effects.
560 citations
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TL;DR: Doping control analyses are generally performed in urine, a matrix that provides a prolonged detection time window, and less often in blood, serum, plasma, hair, saliva, and nails, and to identify the chemical structures of anabolic steroids the use of mass spectrometry detection is very advantageous.
115 citations
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TL;DR: The whole methodology, comprehensive of the homogenization-extraction process and HPLC-MS/MS analysis, has been applied in the analysis of three typical Piedmont (North-West Italy) cheeses, known as Toma Piemontese, Raschera and Castelmagno.
102 citations
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TL;DR: A new HPLC method, with UV and MS(n) detection, for the determination of seven pesticides, including the sulfonylurea herbicides amidosulfuron, azimsulfur, nicosulfuran, rimsulfuron), thifensulfuron methyl, tribenuronmethyl, and the fungicide azoxystrobin characterised by a methoxyacrilate structure is presented.
102 citations
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TL;DR: In the whole, the results obtained for samples of river waters, blood serum, blood plasma, and fish confirm the ubiquitous presence of perfluorinated compounds, as recently denounced by many sources.
97 citations
Cited by
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TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.
Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …
33,785 citations
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2,730 citations
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University of Graz1, Joanneum Research2, Research Institute of Molecular Pathology3, Institute of Molecular Biotechnology4, University of Natural Resources and Life Sciences, Vienna5, Foundation for Research & Technology – Hellas6, Austrian Academy of Sciences7, University of Salzburg8, University of Basel9, University of St Andrews10
TL;DR: This article showed that spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells.
Abstract: Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells. In addition, spermidine administration potently inhibited oxidative stress in ageing mice. In ageing yeast, spermidine treatment triggered epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), suppressing oxidative stress and necrosis. Conversely, depletion of endogenous polyamines led to hyperacetylation, generation of reactive oxygen species, early necrotic death and decreased lifespan. The altered acetylation status of the chromatin led to significant upregulation of various autophagy-related transcripts, triggering autophagy in yeast, flies, worms and human cells. Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
1,230 citations
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TL;DR: A great strength of the subject of pathology is that it bonds strongly with many other medical sciences and specialties and thus occupies the top spot in the field.
Abstract: Pathologic Basis of Diseaseby Stanley L. Robbins is really the fourth edition of hisPathology. Appropriate updating and addition enhance the otherwise identical format, sequence, writing, and illustrations. So many medical students have benefited from this source that it may be the best known general book in the field. I recommend it even more now. Like his former texts, this will be enjoyed for its readability. He clearly lays out a great deal of information. When he includes minutiae, the reasons are clear and one feels that all the material is pertinent. Robbins keeps the whole field in perspective—that is, he does not dwell so long or so heavily on pathologic anatomy or pathogenesis as to tempt the reader to overlook clinical presentation or prognosis. A great strength of the subject of pathology is that it bonds strongly with many other medical sciences and specialties and thus occupies the
1,230 citations
University of Graz1, Joanneum Research2, Research Institute of Molecular Pathology3, Institute of Molecular Biotechnology4, University of Natural Resources and Life Sciences, Vienna5, Foundation for Research & Technology – Hellas6, Austrian Academy of Sciences7, University of Salzburg8, University of Basel9, University of St Andrews10
TL;DR: Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
Abstract: Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells In addition, spermidine administration potently inhibited oxidative stress in ageing mice In ageing yeast, spermidine treatment triggered epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), suppressing oxidative stress and necrosis Conversely, depletion of endogenous polyamines led to hyperacetylation, generation of reactive oxygen species, early necrotic death and decreased lifespan The altered acetylation status of the chromatin led to significant upregulation of various autophagy-related transcripts, triggering autophagy in yeast, flies, worms and human cells Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity
974 citations