Fábio Kiss Ticli

TL;DR: A review of plants showing neutralizing properties against snake venoms which were assayed in research laboratories, correlating them with ethnopharmacological studies, and inhibition of the main pharmacological, toxic and enzymatic activities ofSnake venoms and isolated toxins are presented.

TL;DR: The pure compound potentiated the ability of the commercial equine polyvalent antivenom in neutralizing lethal and myotoxic effects of the crude venom and of isolated PLA2s in experimental models.

TL;DR: An L-amino acid oxidase isolated from Bothrops moojeni snake venom was purified to a high degree using sequential CM-Sepharose ion-exchange and phenyl- Sepharose chromatography, pointing to the potential use of BmooLAAO-I as a therapeutic agent for treatment of diseases in which induction of H(2)O( 2) production can be beneficial.

TL;DR: The antiproteolytic and antihemorrhagic properties of triterpenoid saponin inhibitors from Pentaclethra macroloba are reported against Bothrops snake venoms, and the potential use of these inhibitors to complement antivenom therapy as an alternative treatment and/or used as molecular models for development of new therapeutical agents in the treatment of snake bite envenomations needs to be evaluated.

TL;DR: In this paper, the authors report the antihemorrhagic properties against snake venoms of the aqueous extract of Pentaclethra macroloba (EPema) and demonstrate that EPema is able to totally inhibit a Bothrops jararacussu metalloprotease (BjussuMP-I) induced hemorrhage.