F
Fan Yuan
Researcher at Duke University
Publications - 147
Citations - 17657
Fan Yuan is an academic researcher from Duke University. The author has contributed to research in topics: Vascular permeability & Gene delivery. The author has an hindex of 55, co-authored 139 publications receiving 16681 citations. Previous affiliations of Fan Yuan include City University of New York & Harvard University.
Papers
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Journal ArticleDOI
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
Susan K. Hobbs,Wayne L. Monsky,Fan Yuan,W. G. Roberts,Linda G. Griffith,Vladimir P. Torchilin,Rakesh K. Jain +6 more
TL;DR: Delivery may be less efficient in cranial tumors than in subcutaneous tumors, delivery may be reduced during tumor regression induced by hormonal ablation, and permeability to a molecule is independent of pore cutoff size as long as the diameter of the molecule is much less than the pore diameter.
Journal Article
Vascular Permeability in a Human Tumor Xenograft: Molecular Size Dependence and Cutoff Size
Fan Yuan,Marc Dellian,Dai Fukumura,Michael Leunig,David A. Berk,Vladimir P. Torchilin,Rakesh K. Jain +6 more
TL;DR: Tumor vessels in the model found that tumor vessels in this model were permeable to liposomes of up to 400 nm in diameter, suggesting that the cutoff size of the pores is between 400 and 600nm in diameter.
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Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
TL;DR: The first combined, high-resolution measurements of interstitial pH and pO2 profiles between adjacent vessels in a human tumor xenograft are reported, using fluorescence ratio imaging and phosphorescence quenching microscopy.
Journal Article
Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Fan Yuan,Michael Leunig,Shi Kun Huang,David A. Berk,Demetrios Papahadjopoulos,Rakesh K. Jain +5 more
TL;DR: Microvascular permeability and interstitial penetration of sterically stabilized liposomes in both normal s.c. tissue and human colon adenocarcinoma LS174T xenograft were quantified to provide new insights into the mechanisms of transendothelial pathways ofliposomes and improvements in liposome-mediated drug delivery.
Journal ArticleDOI
Tumor Vascular Permeability, Accumulation, and Penetration of Macromolecular Drug Carriers
Matthew R. Dreher,Wenge Liu,Charles R. Michelich,Mark W. Dewhirst,Fan Yuan,Ashutosh Chilkoti +5 more
TL;DR: Increasing the molecular weight of dextran statistically significantly reduced its tumor vascular permeability and had the highest accumulation in solid tumors but were largely concentrated near the vascular surface.