Fania Szlam

TL;DR: The prospective study of fibrinogen supplementation in acquired bleeding is needed to accurately assess the range of clinical settings in which this management strategy is appropriate, the most effective method of supplementation and a comprehensive safety profile of fibinogen concentrate used for such an approach.

TL;DR: Investigation of hemodynamic responses to 2-30 micro gram/kg remifentanil (escalating doses) injected as a bolus over 1 min during general anesthesia found it associated with a reduction in systolic blood pressure and heart rate and was not associated with alterations in histamine concentration.

TL;DR: Excess protamine weakens clot structure and decreases platelet function; therefore, an increased activated clotting time (ACT) after protamine reversal of heparin may be misinterpreted as residual Heparin anticoagulation.

TL;DR: It is demonstrated in vitro and in vivo that progressive haemodilution decreases endogenous antifibrinolytic proteins including alpha(2)-antiplasmin and thrombin-activatable fibrinoLYsis inhibitor, resulting in increased fibrinogen or FFP tendency, and early fluid replacement therapy with FFP might be advantageous after massive haemorrhage.

TL;DR: It is concluded that rocuronium can be administered safely over a wide range of doses (2‐4 X ED[95]), with minimum hemodynamic effects or histamine release.