Author
Farzin Hadizadeh
Other affiliations: University of Tehran
Bio: Farzin Hadizadeh is an academic researcher from Mashhad University of Medical Sciences. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 27, co-authored 183 publications receiving 2588 citations. Previous affiliations of Farzin Hadizadeh include University of Tehran.
Topics: Chemistry, Medicine, Drug delivery, PLGA, In vivo
Papers published on a yearly basis
Papers
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TL;DR: EpCAM-targeted PEG-PLGA nanopolymersomes will lead to an improved therapeutic index of doxorubicin to EpCAM positive cancer cells, and were significantly more cytotoxic toward EpCam-positive tumor cells (MCF-7) than non- targeted nanopolymeromes.
119 citations
TL;DR: This study proves the potential utility of Apt-DOX-NP for therapeutic application in non-small cell lung cancer and enhances cellular nanoparticle uptake in SK-MES-1 and A549 cell lines and increases the cytotoxicity of the DOX payload as compared with non-targeted DOX- NP.
118 citations
TL;DR: In vivo experiments including whole organ tissue-homogenate analysis and organ fluorescence microscopy imaging of BALB/c mice bearing 4T1 breast adenocarcinoma showed that the folate receptor-targeted QD encapsulated NPs accumulate at tumor sites 6h following intravenous injection, illustrating a high potential of the prepared targeted theranostic nanoplatform in the treatment and imaging of breast cancer.
110 citations
TL;DR: The purity of total crocin extracted from saffron stigmas using crystallization method was extremely higher, about 13 times, more than Fluka product; five other types of crocins in addition to an unknown impurity were seen in its chromatogram.
Abstract: In this study, total crocin was extracted from saffron stigmas using crystallization method. Ethanol 80% was selected as the best extraction solvent. Crystallization process was carried out in one and two steps at different temperatures. Ethanol 80% was used as crystallization medium. Crocin crystals obtained from the first crystallization had low purity and thus were subjected to the second crystallization. The higher purity crystals were yielded in the second crystallization at -5°C. The purity of crocin crystals was studied using UV-visible spectrophotometery and HPLC in comparison with Fluka product and methanolic extract of saffron stigmas. The results indicated that its purity was extremely higher, about 13 times, more than Fluka product. In spite of our expectation, the Fluka product was not a pure α-crocin sample; five other types of crocins in addition to an unknown impurity were seen in its chromatogram. The purity of crystallized total crocin in this work was more than 97%.
108 citations
TL;DR: This review presents up‐to‐date information on the structural and functional aspects of P‐glycoprotein and its known inhibitors and provides some information on drug discovery approaches for candidate P‐gp inhibitors.
102 citations
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Journal Article•
28,685 citations
01 Jan 1999
TL;DR: In this article, anandamide attenuates the pain behavior produced by chemical damage to cutaneous tissue by interacting with CB1-like cannabinoid receptors located outside the central nervous system.
Abstract: The potent analgesic effects of cannabis-like drugs and the presence of CB1-type cannabinoid receptors in pain-processing areas of the brain and spinal cord, indicate that endogenous cannabinoids such as anandamide may contribute to the control of pain transmission within the central nervous system (CNS). Here we show that anandamide attenuates the pain behaviour produced by chemical damage to cutaneous tissue by interacting with CB1-like cannabinoid receptors located outside the CNS. Palmitylethanolamide (PEA), which is released together with anandamide from a common phospholipid precursor, exerts a similar effect by activating peripheral CB2-like receptors. When administered together, the two compounds act synergistically, reducing pain responses 100-fold more potently than does each compound alone. Gas-chromatography/mass-spectrometry measurements indicate that the levels of anandamide and PEA in the skin are enough to cause a tonic activation of local cannabinoid receptors. In agreement with this possibility, the CB1 antagonist SR141716A and the CB2 antagonist SR144528 prolong and enhance the pain behaviour produced by tissue damage. These results indicate that peripheral CB1-like and CB2-like receptors participate in the intrinsic control of pain initiation and that locally generated anandamide and PEA may mediate this effect.
918 citations
TL;DR: This book succeeds Review of Medical Pharmacology, by Meyers, Jawetz, and Goldfien, and deals with relevant information regarding the clinical use of drugs on the various battlefields.
Abstract: This book succeeds Review of Medical Pharmacology , by Meyers, Jawetz, and Goldfien. Edited by B. G. Katzung, some of the important areas covered include drug receptors and pharmacodynamics, pharmacokinetics of absorption and biotransformation of drugs, autonomic pharmacology of cholinergic and adrenergic receptor stimulants and antagonists, antihypertensive agents, cardiac glycosides and other agents used in the treatment of congestive heart failure, therapeutic drugs for cardiac arrhythmias, diuretics, pharmacology of the CNS drugs such as anticonvulsants and anesthetics, antidepressants, narcotic analgesics, nonsteroidal anti-inflammatory agents, endocrine pharmacology, antimicrobial and antimycobacterial drugs, antiprotozoal and antihelmintic drugs, cancer chemotherapy, and drugs and the immune system. Written by several prominent researchers and scientists, each chapter begins with a section on the basic pharmacology, chemistry, pharmacokinetics, and pharmacodynamics of the agents under discussion. This is followed by a section on clinical pharmacology, which deals with relevant information regarding the clinical use of drugs on the various
859 citations