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Author

Fatma M. El-Demerdash

Other affiliations: Henan University
Bio: Fatma M. El-Demerdash is an academic researcher from Alexandria University. The author has contributed to research in topics: Lipid peroxidation & Antioxidant. The author has an hindex of 25, co-authored 42 publications receiving 3482 citations. Previous affiliations of Fatma M. El-Demerdash include Henan University.


Papers
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TL;DR: Investigation of the potential protective effects of vitamin E and beta-carotene alone or in combination against cadmium (Cd) toxicity demonstrated the beneficial influences ofitamin E, -carotenes alone and/or in combination in reducing the harmful effects of CdCl2.

492 citations

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TL;DR: In this article, the effects of onion and garlic juices on biochemical parameters, enzyme activities and lipid peroxidation in alloxan-induced diabetic rats were investigated, and the results showed that garlic and onion juices exerted antioxidant and antihyperglycemic effects.

460 citations

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TL;DR: VE and Se have beneficial effects and could be able to antagonize Al toxicity, and VE or Se in combination with Al partially or totally alleviated its toxic effects on the studied parameters.

298 citations

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TL;DR: Different doses of acrylamide exerted deterioration effects on enzyme activities and lipid peroxidation in a dose-dependent manner and significantly reduced the content of sulfhydryl groups and protein in different tissues.

235 citations

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TL;DR: It can be concluded that curcumin has beneficial influences and could be able to antagonize Sa toxicity and reduce the induction in the levels of TBARS and induced the decrease in the activities of antioxidant enzymes and the Levels of SH-groups.

211 citations


Cited by
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01 Jan 2016
TL;DR: Methods Of Enzymatic Analysis is universally compatible behind any devices to read, and in the authors' digital library an online admission to it is set as public appropriately so you can download it instantly.
Abstract: Rather than enjoying a fine ebook as soon as a mug of coffee in the afternoon, instead they juggled when some harmful virus inside their computer. Methods Of Enzymatic Analysis is clear in our digital library an online admission to it is set as public appropriately you can download it instantly. Our digital library saves in complex countries, allowing you to get the most less latency period to download any of our books considering this one. Merely said, the Methods Of Enzymatic Analysis is universally compatible behind any devices to read.

1,136 citations

Journal ArticleDOI
TL;DR: Decreased performance in areas of motor function and memory has been reported among children exposed to presumably safe mercury levels and disruption of attention, fine motorfunction and verbal memory was also found in adults on exposure to low mercury levels.

963 citations

Journal Article
TL;DR: A comprehensive account of recent developments in the research on heavy metal poisoning particularly the role of oxidative stress/free radicals in the toxic manifestation is attempted, an update about the recent strategies for the treatment with chelating agents and a possible beneficial role of antioxidants supplementation to achieve the optimum effects are attempted.
Abstract: Exposure to heavy metals is a common phenomenon due to their environmental pervasiveness. Metal intoxication particularly neurotoxicity, genotoxicity, or carcinogenicity is widely known. This review summarizes our current understanding about the mechanism by which metalloids or heavy metals (particularly arsenic, lead, cadmium and mercury) induce their toxic effects. The unifying factor in determining toxicity and carcinogenicity for all these metals is the generation of reactive oxygen and nitrogen species. The toxic manifestations of these metals are caused primarily due to imbalance between pro-oxidant and antioxidant homeostasis which is termed as oxidative stress. Besides these metals have high affinity for thiol groups containing enzymes and proteins, which are responsible for normal cellular defense mechanism. Long term exposure to these metals could lead to apoptosis. Signaling components affected by metals include growth factor receptors, G-proteins, MAP kinases and transcription factors. Chelation therapy with chelating agents like calcium disodium ethylenediamine tetra acetic acid (CaNa(2)EDTA), British Anti Lewisite (BAL), sodium 2,3-dimercaptopropane 1-sulfonate (DMPS), meso 2,3-dimercaptosuccinic acid (DMSA) etc., is considered to be the best known treatment against metal poisoning. Despite many years of research we are still far away from effective treatment against toxicity caused due to exposure to heavy metals/metalloids. The treatment with these chelating agents is compromised with number of serious side-effects. Studies show that supplementation of antioxidants along-with a chelating agent prove to be a better treatment regimen than monotherapy with chelating agents. This review attempts a comprehensive account of recent developments in the research on heavy metal poisoning particularly the role of oxidative stress/free radicals in the toxic manifestation, an update about the recent strategies for the treatment with chelating agents and a possible beneficial role of antioxidants supplementation to achieve the optimum effects. We have selected only arsenic, lead, mercury and cadmium for this article keeping in view current concerns and literature available.

840 citations

Journal ArticleDOI
TL;DR: The current review gives an overview on Cd-induced ROS production and anti-oxidative defense in organisms under different Cd regimes and the C d-induced oxidative challenge is discussed with a focus on damage and signaling as downstream responses.
Abstract: At the cellular level, cadmium (Cd) induces both damaging and repair processes in which the cellular redox status plays a crucial role. Being not redox-active, Cd is unable to generate reactive oxygen species (ROS) directly, but Cd-induced oxidative stress is a common phenomenon observed in multiple studies. The current review gives an overview on Cd-induced ROS production and anti-oxidative defense in organisms under different Cd regimes. Moreover, the Cd-induced oxidative challenge is discussed with a focus on damage and signaling as downstream responses. Gathering these data, it was clear that oxidative stress related responses are affected during Cd stress, but the apparent discrepancies observed in between the different studies points towards the necessity to increase our knowledge on the spatial and temporal ROS signature under Cd stress. This information is essential in order to reveal the exact role of Cd-induced oxidative stress in the modulation of downstream responses under a diverse array of conditions.

835 citations