F
Federica Santoro
Researcher at Karolinska Institutet
Publications - 13
Citations - 606
Federica Santoro is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: DNA methylation & Genomic imprinting. The author has an hindex of 9, co-authored 13 publications receiving 511 citations. Previous affiliations of Federica Santoro include Austrian Academy of Sciences.
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Journal ArticleDOI
Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line
Patrick Essletzbichler,Tomasz Konopka,Federica Santoro,Doris Chen,Bianca V. Gapp,Robert Kralovics,Thijn R. Brummelkamp,Thijn R. Brummelkamp,Sebastian M.B. Nijman,Tilmann Bürckstümmer +9 more
TL;DR: In this paper, the authors employed a CRISPR/Cas9-based genome engineering strategy to excise this sizeable chromosomal fragment and to efficiently and reproducibly derive clones that retain their haploid state.
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Programming and reprogramming a human heart cell
TL;DR: The fundamental principles that govern the “programming” and “reprogramming" of a human heart cell are considered and updated therapeutic strategies to regenerate a damaged heart are discussed.
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Imprinted Igf2r silencing depends on continuous Airn lncRNA expression and is not restricted to a developmental window
Federica Santoro,Daniela Mayer,Ruth M. Klement,Katarzyna E. Warczok,Alexey Stukalov,Denise P. Barlow,Florian M. Pauler +6 more
TL;DR: It is shown that Airn expression is both necessary and sufficient to silence Igf2r throughout ESC differentiation and that the somatic methylation imprint, although not required to initiate or maintain silencing, adds a secondary layer of repressive epigenetic information.
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Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract.
Makoto Sahara,Federica Santoro,Jesper Sohlmer,Chikai Zhou,Nevin Witman,Chuen Yan Leung,Mimmi M. Mononen,Kristine Bylund,Peter J. Gruber,Kenneth R. Chien +9 more
TL;DR: Comprehensive gene expression profiles of human cardiac derivatives from multipotent CPCs to intermediates and mature cardiac cells by population and single-cell RNA-seq using human embryonic stem cell-derived and embryonic/fetal heart-derived cardiac cells micro-dissected from specific heart compartments are reported.
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Silencing and transcriptional properties of the imprinted Airn ncRNA are independent of the endogenous promoter
Stefan H. Stricker,Laura Steenpass,Florian M. Pauler,Federica Santoro,Paulina A. Latos,Ru Huang,Martha V. Koerner,Mathew A. Sloane,Katarzyna E. Warczok,Denise P. Barlow +9 more
TL;DR: It is shown by deletion of the Airn ncRNA promoter and replacement with a constitutive strong or weak promoter that splicing suppression and termination, as well as silencing activity, are maintained by strong Airn expression from an exogenous promoter.