F
Federico Perez
Researcher at Case Western Reserve University
Publications - 160
Citations - 8492
Federico Perez is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Acinetobacter baumannii & Klebsiella pneumoniae. The author has an hindex of 46, co-authored 147 publications receiving 7130 citations. Previous affiliations of Federico Perez include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
Global Challenge of Multidrug-Resistant Acinetobacter baumannii
Federico Perez,Andrea M. Hujer,Kristine M. Hujer,Brooke K. Decker,Philip N. Rather,Robert A. Bonomo,Robert A. Bonomo +6 more
TL;DR: This review summarizes the worldwide emergence of antibiotic-resistant A. baumannii as a nosocomial pathogen and focuses on its mechanisms of resistance against selected antibiotics.
Journal ArticleDOI
Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae
David van Duin,Judith J. Lok,Michelle Earley,Eric Cober,Sandra S. Richter,Federico Perez,Federico Perez,Robert A. Salata,Robert C. Kalayjian,Richard R. Watkins,Richard R. Watkins,Yohei Doi,Keith S Kaye,Vance G. Fowler,David L. Paterson,Robert A. Bonomo,Robert A. Bonomo,Scott R. Evans +17 more
TL;DR: Ceftazidime-avibactam may be a reasonable alternative to colistin in the treatment of K. pneumoniae carbapenemase-producing CRE infections and require confirmation in a randomized controlled trial.
Journal ArticleDOI
Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study
Belén Gutiérrez-Gutiérrez,Elena Salamanca,Marina de Cueto,Po-Ren Hsueh,Pierluigi Viale,José Ramón Paño-Pardo,Mario Venditti,Mario Tumbarello,George L. Daikos,Rafael Cantón,Yohei Doi,Felipe Francisco Tuon,Ilias Karaiskos,Elena Pérez-Nadales,Mitchell J. Schwaber,Mitchell J. Schwaber,Özlem Kurt Azap,Maria Souli,Emmanuel Roilides,Spyros Pournaras,Murat Akova,Federico Perez,Joaquín Bermejo,Antonio Oliver,Manel Almela,Warren Lowman,Benito Almirante,Robert A. Bonomo,Robert A. Bonomo,Yehuda Carmeli,Yehuda Carmeli,David L. Paterson,Álvaro Pascual,Álvaro Pascual,Jesús Rodríguez-Baño,Jesús Rodríguez-Baño,M.D. del Toro,Jorge Galvez,Marco Falcone,Alessandro Russo,Helen Giamarellou,Enrico Maria Trecarichi,Angela Raffaella Losito,E. García-Vázquez,Alicia Hernandez,J. Gómez,Germán Bou,Elias Iosifidis,N. Prim,Ferran Navarro,Beatriz Mirelis,Anna Skiada,Julia Origüen,R. San Juan,Mario Fernández-Ruiz,Nieves Larrosa,Mireia Puig-Asensio,José Miguel Cisneros,José Molina,V. González,V. Rucci,E. Ruiz de Gopegui,C. I. Marinescu,Luis Martínez-Martínez,M.C. Fariñas,M. E. Cano,Mónica Gozalo,Marta Mora-Rillo,C. Navarro-San Francisco,Carmen Peña,Silvia Gómez-Zorrilla,Fe Tubau,Athanassios Tsakris,O. Zarkotou,Anastasia Antoniadou,Garyphallia Poulakou,Johann D. D. Pitout,Deepali Virmani,J. Torre-Cisneros,Julia Guzmán-Puche,Ö. Helvaci,A. O. Sahin,Vicente Pintado,Patricia Cordero Ruiz,Michele Bartoletti,Maddalena Giannella,Evelina Tacconelli,F. Riemenschneider,Esther Calbo,Cristina Badia,M. Xercavins,Oriol Gasch,D. Fontanals,E. Jové +93 more
TL;DR: Patients with BSIs due to CPE should receive active therapy as soon as they are diagnosed, and monotherapy should be considered for those in the low-mortality-score stratum.
Journal ArticleDOI
The continuing challenge of esbls
Federico Perez,Andrea Endimiani,Andrea Endimiani,Kristine M. Hujer,Robert A. Bonomo,Robert A. Bonomo +5 more
TL;DR: Structural studies of ESBLs indicate that active site expansion and remodeling are responsible for this extended hydrolytic activity, and most relevant are the increasing concerns regarding the status of carbapenems as 'best therapy' for ESBL-producing bacteria in light of the emergence ofcarbapenemases.
Journal ArticleDOI
Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA
Andrea Endimiani,Andrea M. Hujer,Federico Perez,Christopher R. Bethel,Kristine M. Hujer,Kristine M. Hujer,J. Kroeger,Margret Oethinger,David L. Paterson,Mark Raymond Adams,Michael R. Jacobs,Daniel J. Diekema,Gerri S. Hall,Stephen G. Jenkins,Louis B. Rice,Fred C. Tenover,Robert A. Bonomo,Robert A. Bonomo +17 more
TL;DR: The complex beta-lactamase background of KPC-Kp isolates that are emerging in multiple centres in the Eastern USA demonstrated the prevalence of a single dominant clone suggests that interstate transmission has occurred.