Fei Guo

TL;DR: This study shows that Sars-CoV-2 perturbs host innate immune response via both its structural and nonstructural proteins, and thus provides insights into the pathogenesis of SARS-Cov-2.

TL;DR: The interferon-inducible myxovirus resistance (Mx) proteins play important roles in combating a wide range of virus infections, but the antiviral activity of MxB is less well established.

TL;DR: Evidence against an RNA bridge facilitating the Gag/APOBEC3G interaction includes data indicating that 1) the incorporation of APOB EC3G occurs independently of viral genomic RNA, 2) a Gag-APOBec3G complex is immunoprecipitated from cell lysate after RNase treatment, and 3) the zinc coordination motif, rather than the regions flanking this motif, have been implicated in RNA binding in another family member, APOBEC1.

TL;DR: Using HIV-1, it is demonstrated that many of these indels are indeed lethal for the virus, but that others lead to the emergence of replication competent viruses that are resistant to Cas9/sgRNA.

TL;DR: Evidence is provided here that a decrease in the synthesis of the DNA by reverse transcriptase may account for a significant part of the reduction in DNA production in cells with Vif-negative HIV-1, and this reduction can occur independently of DNA deamination.