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Felix Espinoza
Researcher at National Autonomous University of Nicaragua
Publications - 17
Citations - 2785
Felix Espinoza is an academic researcher from National Autonomous University of Nicaragua. The author has contributed to research in topics: Rotavirus & Diarrhea. The author has an hindex of 12, co-authored 17 publications receiving 2487 citations. Previous affiliations of Felix Espinoza include University of Chile.
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Journal ArticleDOI
Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis
Guillermo M. Ruiz-Palacios,Irene Pérez-Schael,F. Raúl Velázquez,Hector Abate,Thomas Breuer,Sue Ann Costa Clemens,Brigitte Cheuvart,Felix Espinoza,Paul Gillard,Bruce L. Innis,Yolanda Cervantes,Alexandre da Costa Linhares,Pio Lopez,Mercedes Macias-Parra,Eduardo Ortega-Barria,Vesta Richardson,Doris Maribel Rivera-Medina,Luis Rivera,Belén Salinas,Noris Pavía-Ruz,Jorge Salmerón,Ricardo Rüttimann,Juan Carlos Tinoco,Pilar Rubio,Ernesto Nuñez,M. Lourdes Guerrero,Juan Pablo Yarzabal,Silvia Damaso,Nadia Tornieporth,Xavier Sáez-Llorens,Rodrigo Vergara,Timo Vesikari,Alain Bouckenooghe,Ralf Clemens,Beatrice De Vos,Miguel O'Ryan +35 more
TL;DR: Two oral doses of the live attenuated G1P[8] HRV vaccine were highly efficacious in protecting infants against severe rotavirus gastroenteritis, significantly reduced the rate of severe gastroenteropathy from any cause, and were not associated with an increased risk of intussusception.
Journal ArticleDOI
Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study.
Alexandre da Costa Linhares,F. Raúl Velázquez,Irene Pérez-Schael,Xavier Sáez-Llorens,Hector Abate,Felix Espinoza,Pio Lopez,Mercedes Macias-Parra,Eduardo Ortega-Barria,Doris Maribel Rivera-Medina,Luis Rivera,Noris Pavía-Ruz,Ernesto Nuñez,Silvia Damaso,Guillermo M. Ruiz-Palacios,Beatrice De Vos,Miguel O'Ryan,Paul Gillard,Alain Bouckenooghe +18 more
TL;DR: Two doses of RIX4414 were effective against severe rotavirus gastroenteritis during the first 2 years of life in a Latin American setting and inclusion of Rix4414 in routine paediatric immunisations should reduce the burden of rotav virus gastroEnteritis worldwide.
Journal ArticleDOI
Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents
Shibadas Biswal,Humberto Reynales,Xavier Sáez-Llorens,Pio Lopez,Charissa Borja-Tabora,Pope Kosalaraksa,Chukiat Sirivichayakul,Veerachai Watanaveeradej,Luis Rivera,Felix Espinoza,LakKumar Fernando,Reynaldo Dietze,Kleber Giovanni Luz,Rivaldo Venâncio da Cunha,José Jimeno,Eduardo López-Medina,Astrid Borkowski,Manja Brose,Martina Rauscher,Inge Lefevre,Svetlana Bizjajeva,Lulu Bravo,Derek Wallace +22 more
TL;DR: TAK-003 was efficacious against symptomatic dengue in countries in which the disease is endemic and the incidence of serious adverse events was similar in the vaccine group and placebo group.
Journal ArticleDOI
Efficacy of a tetravalent dengue vaccine in healthy children aged 4-16 years: a randomised, placebo-controlled, phase 3 trial.
Shibadas Biswal,Charissa Borja-Tabora,Luis Vargas,Hector Velásquez,Maria Theresa Alera,Victor Sierra,Edith Johana Rodriguez-Arenales,Delia Yu,V. Pujitha Wickramasinghe,Edson D. Moreira,Asvini D. Fernando,Dulanie Gunasekera,Pope Kosalaraksa,Felix Espinoza,Eduardo López-Medina,Lulu Bravo,Suely Tuboi,Yanee Hutagalung,Pedro Garbes,Ian Escudero,Martina Rauscher,Svetlana Bizjajeva,Inge Lefevre,Astrid Borkowski,Xavier Sáez-Llorens,Derek Wallace,Alys Concepción,Ana Cecilia Villarreal,Asvini Fernando,Chukiat Sirivichayakul,Edith Johanna Rodriguez-Arenales,Humberto Reynales,Kleber Giovanni Luz,José Jimeno,LakKumar Fernando,Luis Rivera,Onanong Manacharoen,Pio Lopez,Reynaldo Dietze,Rivaldo Venâncio da Cunha,Veerachai Watanaveeradej,Manja Brose,Kelley Moss,Seetha Meyer,Vianney Tricou +44 more
TL;DR: TAK-003 was well tolerated and efficacious against symptomatic dengue in children regardless of serostatus before immunisation, warranting continued follow-up to assess longer-term vaccine performance.
Journal ArticleDOI
Etiology of childhood diarrhea after rotavirus vaccine introduction: a prospective, population-based study in Nicaragua.
Sylvia Becker-Dreps,Filemon Bucardo,Samuel Vilchez,Luis Enrique Zambrana,Lan Liu,David J. Weber,Rodolfo Peña,Leslie Barclay,Jan Vinjé,Michael G. Hudgens,Johan Nordgren,Lennart Svensson,Douglas R. Morgan,Douglas R. Morgan,Felix Espinoza,Margarita Paniagua +15 more
TL;DR: In this Central American community after RV5 introduction, rotavirus was not commonly detected among children with diarrhea, and prevention and appropriate management of norovirus and sapovirus should be considered to further reduce the burden of diarrheal disease.