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Felix Kratz

Bio: Felix Kratz is an academic researcher from University of Freiburg. The author has contributed to research in topics: Drug carrier & Drug delivery. The author has an hindex of 6, co-authored 7 publications receiving 2705 citations.

Papers
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Journal ArticleDOI
TL;DR: This review gives an account of the different drug delivery systems which make use of albumin as a drug carrier with a focus on those systems that have reached an advanced stage of preclinical evaluation or that have entered clinical trials.

1,913 citations

Journal ArticleDOI
TL;DR: An overview of the expanding field of preclinical and clinical drug applications and developments that use albumin as a protein carrier to improve the pharmacokinetic profile of the drug or to target the drug to the pathogenic site addressing diseases with unmet medical needs is given.

716 citations

Journal ArticleDOI
TL;DR: Because albumin as the most abundant circulating protein cannot only be used to improve the pharmacokinetic profile of therapeutically relevant peptides and the targeting moiety of antibodies but also for peptide-based targeting as well as low-molecular weight drugs to inflamed or malignant tissue, it is anticipated that R&D efforts of academia and the pharmaceutical industry in this field of drug delivery will prosper.

317 citations

BookDOI
19 Oct 2011
TL;DR: Polymer-Based Combination Therapy in Cancer Clinical Experience with Drug-Polymer Conjugates Future Trends, Challenges, and Opportunities with Polymer-based Combination therapy.
Abstract: Volume 1: PRINCIPLES OF TUMOR TARGETING Limits of Conventional Cancer Chemotherapy Pathophysiological and Vascular Characteristics of Tumors in Relation to Drug Delivery Enhanced Permeability and Retention Effect in Relation to Tumor Targeting Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design Development of Cancer-Targeting Ligands and Ligand-Drug Conjugates Antibody-Directed Enzyme Prodrug Therapy (ADEPT) - Basic Principles and its Practice So Far TUMOR IMAGING Imaging Techniques in Drug Development and Clinical Practice Magnetic Nanoparticles in Magnetic Resonance Imaging and Drug Delivery Preclinical and Clinical Tumor Imaging with SPECT/CT and PET/CT Volume 2: MACROMOLECULAR DRUG DELIVERY SYSTEMS Antibody-Based Systems Empowered Antibodies for Cancer Therapy Mapping Accessible Vascular Targeting to Penetrate Organs and Solid Tumors Considerations of Linker Technologies Antibody-Maytansinoid Conjugates: From the Bench to the Clinic Calicheamicin Antibody-Drug Conjugates and Beyond Antibodies for the Delivery of Radionuclides Bispecific Antibodies and Immune Therapy Targeting POLYMER-BASED SYSTEMS Design of Polymer-Drug Conjugates Dendritic Polymers in Oncology: Facts, Features, and Applications Site-Specific Prodrug Activation and the Concept of Self-Immolation Ligand-Assisted Vascular Targeting of Polymer Therapeutics Drug Conjugates with Poly(Ethylene)Glycole Thermo-Responsive Polymers Polysaccharide-Based Drug Conjugates for Tumor Targeting Serum Proteins as Drug Carriers of Anticancer Agents Future Trends, Challenges, and Opportunities with Polymer-Based Combination Therapy in Cancer Clinical Experience with Drug-Polymer Conjugates NANO- AND MICROPARTICULATE DRUG DELIVERY SYSTEMS - LIPID-BASED SYSTEMS Overview on Nanocarriers as Delivery Systems Development of PEGylated Liposomes Immunoliposomes Responsive Liposomes (for Solid Tumor Therapy) Nanoscale Delivery Systems for Combination Chemotherapy NANO- AND MICROPARTICULATE DRUG DELIVERY SYSTEMS - POLYMER-BASED SYSTEMS Micellar Strcutures as Drug Delivery Systems Tailor-Made Hydrogels for Tumor Delivery pH-Triggered Micelles for Tumor Delivery Albumin-Drug Nanoparticles Carbon Nanotubes Volume 3: LIGAND-BASED DRUG DELIVERY SYSTEMS Cell-Penetrating Peptides in Cancer Targeting Targeting to Peptide Receptors Aptamer Conjugates: Emerging Delivery Platforms for Targeted Cancer Therapy Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors Drug Conjugates with Polyunsaturated Fatty Acids SPECIAL TOPICS RNA Drug Delivery Approaches Local Gene Delivery for Therapy of Solid Tumors Viral Vectors for RNA Interference Applications in Cancer Research and Therapy Design of Targeted Protein Toxins Drug Targeting to the Central Nervous System Liver Tumor Targeting Photodynamic Therapy: Photosensitizers Targeting and Delivery Tumor-Targeting Strategies with Anticancer Platinum Complexes

61 citations

Journal ArticleDOI
01 Jul 2010

34 citations


Cited by
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Journal ArticleDOI
TL;DR: This paper presents a meta-modelling study of the response of the immune system to chemotherapy and its applications in the context of central nervous system disorders.
Abstract: Sasidharan Swarnalatha Lucky,†,§ Khee Chee Soo,‡ and Yong Zhang*,†,§,∥ †NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, Singapore, Singapore 117456 ‡Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore 169610 Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore 117576 College of Chemistry and Life Sciences, Zhejiang Normal University, Zhejiang, P. R. China 321004

2,194 citations

Journal ArticleDOI
TL;DR: A historical review of the EPR effect, including its features, vascular mediators found in both cancer and inflamed tissue, and methods of augmentation of theEPR effect are described, that result in better tumor delivery and improved therapeutic effect.

1,900 citations

Journal ArticleDOI
TL;DR: HSA is a valuable biomarker of many diseases, including cancer, rheumatoid arthritis, ischemia, post-menopausal obesity, severe acute graft-versus-host disease, and diseases that need monitoring of the glycemic control.

1,257 citations

Journal ArticleDOI
TL;DR: Chemistries that Facilitate Nanotechnology Kim E. Sapsford,† W. Russ Algar, Lorenzo Berti, Kelly Boeneman Gemmill,‡ Brendan J. Casey,† Eunkeu Oh, Michael H. Stewart, and Igor L. Medintz .
Abstract: Chemistries that Facilitate Nanotechnology Kim E. Sapsford,† W. Russ Algar, Lorenzo Berti, Kelly Boeneman Gemmill,‡ Brendan J. Casey,† Eunkeu Oh, Michael H. Stewart, and Igor L. Medintz*,‡ †Division of Biology, Department of Chemistry and Materials Science, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, United States ‡Center for Bio/Molecular Science and Engineering Code 6900 and Division of Optical Sciences Code 5611, U.S. Naval Research Laboratory, Washington, D.C. 20375, United States College of Science, George Mason University, 4400 University Drive, Fairfax, Virginia 22030, United States Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, California 95817, United States Sotera Defense Solutions, Crofton, Maryland 21114, United States

1,169 citations