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Showing papers by "Feng Zhang published in 2003"


Journal Article
TL;DR: OECs transplantation can improve the neurological function of spinal cord of SCI patients regardless of their ages, and Restoration of pin prick in > 51 years group was better than other age groups except 21 - 30 years group.
Abstract: Objective To evaluate the restoration of function after spinal cord injury (SCI) in patients of different ages who have underwent intraspinal transplantation of olfactory ensheathing cells ( OECs). Methods One hundred andseventy-one SCI patients were included in this study. Of them, 139 were male and 32 were female, with age ranging from 2 to 64 years ( mean, 34. 9 years). In all SCI patients the lesions were injected at the time of operation with OECs. According to their ages, the patients were divided into 5 groups: ≤20 years group (n =9), 21 -30 years group (n = 54), 31 -40 years group (n=60), 41 -50 years group (n=34) and >51 years group (n = 14). The spinal cord function was assessed based on the American Spinal Injury Association (ASIA) Classification System before and 2 - 8 weeks after OECs transplantation. One-way ANOVA and q test were used for statistical analysis, and the data were expressed as mean ′ SD. Results After surgery, the motor scores increased by 5. 2 ′ 4.8, 8.6 ′ 8.0, 8. 3 ′ 8.8, 5.7 ′ 7.3 and 8. 2 ′7. 6 in 5 age groups respectively (F=1.009, P = 0. 404); light touch scores increased by 13.9 ′ 8.1, 15.5 ′ 14.3, 12.0 ′ 14.4, 14. 1 ′ 18.5 and 24.8 ′ 25.3 respectively (F=1.837, P= 0. 124); and pin prick scores increased by 11.1 ′ 7.9, 17. 2 ′ 14.3, 13. 2 ′ 11., 13. 6 ′ 13.9 and 25.4 ′ 24.3 respectively (F=2.651, P =0.035). Restoration of pin prick in >51 years group was better than other age groups except 21 -30 years group. Conclusion OECs transplantation can improve the neurological function of spinal cord of SCI patients regardless of their ages. Further research into the long-term outcomes of the treatment will be required.

180 citations


Journal ArticleDOI
TL;DR: In this paper, the protein adsorption behavior was investigated in a HSA/HFG binary system by means of 125I labeling, and the results showed that both proteins adsorbed preferentially on LTI-carbon rather than on titanium oxide film.

18 citations


Journal ArticleDOI
TL;DR: In this paper, living-related liver transplantation (LRLT) for Wilson's disease (WD) patients with the fulminant form and end-stage liver failure was discussed.
Abstract: AIM: Liver transplantation is indicated for Wilson’s disease (WD) patients with the fulminant form and end-stage liver failure. The aim of this study was to review our experience with living-related liver transplantation (LRLT) for WD. METHODS: A retrospective review was made for WD undergoing LRLT at our hospital from January 2001 to Febuary 2003. RESULTS: LRLT was carried out in 15 patients with WD, one of them had fulminant hepatic failure and the others had end-stage hepatic insufficiency. The mean age of the patients was 14.5 ± 2.5 years (range 6 to 20 years). All the recipients had low serum ceruloplasmin levels with a mean value of 126.8 ± 34.8 mg/L before transplantation. The serum ceruloplasmin levels increased to an average of 238.6 ± 34.4 mg/L after LRLT at the latest evaluation, between 2 and 27 months after transplantation. A marked reduction in urinary copper excretion was observed in all the recipients after transplantation. Among the eight recipients with preoperative Kayser-Fleischer (K-F) rings, this abnormality resolved completely after LRLT in five patients and partially in three. All the recipients are alive and remain well, and none has developed signs of recurrent WD after a mean follow-up period of 15.4 ± 9.3 months (range 2-27 months) except one who died of severe rejection. The donors were 14 mothers and 1 father. The serum ceruloplasmin levels were within normal limits in all the donors (mean: 220 ± 22.4 mg/L). The mean donor age was 35.0 ± 4.0 years (range, 30 to 45 years). Two donors had biliary leakage and required reoperation. Grafts were harvested as follows: four right lobe grafts without hepatic middle vein and eleven left lobe grafts with hepatic middle vein. The grafts were blood group-compatible in all recipents. Two patients had hepatic artery thrombosis and underwent retransplantation. CONCLUSION: LRLT is a curative procedure in Wilson’s disease manifested as fulminant hepatic failure and/or end-stage hepatic insufficiency. After liver transplantation, the serum ceruoplasmin level can increase to its normal range while urinary copper excretion decreases. Grafts chosen from heterozygote carriers do not appear to confer any risk of recurrence in recipients.

15 citations


Journal Article
TL;DR: Living donor liver transplantation is effective treatment for WD complicated with nervous system symptom, ceruloplasmin is normal and Kayser-Fleischer ring and nervous system symptoms are to various extents.
Abstract: OBJECTIVE To investigate living donor liver transplantation for Wilson disease with neurologic features. METHODS From Jan 2001 to Mar 2003, fifteen cases of living donor liver transplantation were performed for Wilson Disease (WD), five of those were complicated with neurologic features. A retrospective analysis was given for cooper metabolism and neurologic features. RESULTS All operation were living related liver transplantation and donors were mothers. Four left lobes with hepatic middle vein and one right lobe without hepatic middle vein were harvested from donors, and graft volume to recipient body weight ratio was 0.79 approximately 1.08. One patient occurred hepatic artery thrombosis and performed retransplantation later, the other recipients recovered satisfactorily. All patients showed Extrapyramidal sign and three patients companying with language handicap and dyskinesia alleviated postoperation follow-up between 2 and 16 months. All recipients are alive and remain well, and none have developed signs of recurrent WD. CONCLUSION Living donor liver transplantation is effective treatment for WD complicated with nervous system symptom, ceruloplasmin is normal and Kayser-Fleischer ring and nervous system symptom are to various extents.

2 citations


Journal Article
TL;DR: The procedure of LDLT is relatively safe for the donor, and the recipients recovered and were discharged from hospital, whose liver function and cuprum oxidase had returned to normal.
Abstract: OBJECTIVE To investigate some principal surgical techniques of living donor liver transplantation (LDLT) METHODS Eleven patients of LDLT have been performed at our department from January 2001 to March 2002 The left lobe (segments II, III, IV, including the middle hepatic veins) was transplanted in 8 patients, the left lateral lobe (segments II, III) in one and the right lobe (segments V, VI, VII, VIII, not including the middle hepatic veins) in 2 The plane of liver resection was determined on the basis of donor liver volumetry using CT scan and the anatomic analysis of vascular structure of the hepatic vein, portal vein and hepatic artery using intraoperative ultrasound The hepatic parenchyma was transected using ultrasound aspirator without blood vessel clamping or graft manipulation The isolated graft was perfused in situ through the portal vein branch The liver graft was transplanted into the recipients who underwent total hepatectomy with preservation of the inferior vena cava The hepatic vein reconstruction was performed in end to end fashion or end to side to the vena cava after venoplasty Arterial anastomoses were performed using microsurgical technique Biliary reconstruction was made by using duct-to-duct anastomosis and placement of a T tube RESULTS All the 11 donors are uneventfully discharged after operation In the 11 recipients, an 8-year-old girl needed retransplantation because of hepatic artery thrombosis, one case died of serious chronic rejection on the postoperative day 72 Ten recipients recovered and were discharged from hospital, whose liver function and cuprum oxidase had returned to normal CONCLUSIONS The procedure of LDLT is relatively safe for the donor Reconstruction of vessels is a key step in the procedure Comprehending anatomical variation of vessels pre- and intra-operatively and correct surgical management might reduce the incidence of complications

2 citations


Journal ArticleDOI
TL;DR: This paper reviews seven areas of crop production and ecophysiology research in the context of the geo-climatic conditions of the extreme North American humid northeast and finds progress has been made in each and there is now a longer-term need to integrate some of these findings at the cropping system level.
Abstract: SUMMARY Crop production in the northeastern North America poses unique challenges in that soils tend to be cool and wet in the spring, and there is only a brief period each summer when sufficient heat is obtained for the growth of the main crops produced in the area. This paper reviews seven areas of crop production and ecophysiology research in the context of the geo-climatic conditions of the extreme North American humid northeast. The seven areas are: (1) intercropping systems, (2) leafy reduced-stature corn, (3) intensive cereal management, (4) production of C4 grasses, (5) development of a chronic injection system for physiology research, (6) legume-to-rhizobia signals and inhibition of soybean nodulation, and (7) rhizobia-to-legume signals and crop growth. Progress has been made in each area and there is now a longer-term need to integrate some of these findings at the cropping system level.

1 citations