Author
Feng Zhang
Other affiliations: Cincinnati Children's Hospital Medical Center, Nanjing Medical University, Peking Union Medical College Hospital ...read more
Bio: Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Materials science. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
Topics: Medicine, Materials science, Computer science, CRISPR, Biology
Papers published on a yearly basis
Papers
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01 Dec 1997-Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms
TL;DR: In this article, it was found that the O Ti ratio of films deposited is less than 2 : 1 and that Ti2+, Ti3+ and Ti4+ chemical states exist on the titanium oxide films.
Abstract: Titanium dioxide films were prepared by ion beam enhanced deposition (IBED), where the films were synthesized by depositing titanium atoms and simultaneously bombarding with Ne+, Ar+ and Xe+ ion beams respectively at an energy of 40 keV in an O2 environment. Rutherford backscattering spectroscopy (RBS), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD) and Raman spectroscopy were used to characterize the deposited films. It was found that the O Ti ratio of films deposited is less than 2 : 1. XPS analysis shows that Ti2+, Ti3+ and Ti4+ chemical states exist on the titanium oxide films. The films deposited at different ion beam bombardment are principally crystalline TiO2 with a rutile structure. The films deposited with Ne+ bombardment exhibit a (1 0 0) preferred orientation. Films deposited with Xe+ bombardment exhibit a high (1 0 0) orientation and increase the (1 0 0) orientation with decreasing ion beam current density. The lattice parameter of the deposited films is larger than that of bulk materials. The grain size of the films is between 20 and 60 nm and decreases with increasing mass of bombarding ions.
10 citations
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TL;DR: In this paper, a new method to improve the morphology and the microstructure of sputtered bismuth-substituted garnet films for optical storage is discussed, which employs a high ramp up rate and recurrent annealing as well as quenching in an air environment.
Abstract: A new method to improve the morphology and the microstructure of sputtered bismuth‐substituted garnet films for optical storage is discussed. The method employs a high ramp up rate and recurrent annealing as well as quenching in an air environment, which results in smaller grain size, smoother surface, and less void volume in the garnet films than that from a conventional oven annealing. We have discovered that samples prepared with a more recurrent annealing only appeared as a single garnet phase, and the samples with a less recurrent annealing appeared as a garnet phase as well as DyFeO3 phase. We observed the microstructure of the annealed films with scanning electron microscopy (SEM). By applying the new method, the as‐deposited films had been successfully crystallized to the (BiDy)3(FeGa)5O12 garnet phase with the grain size of about 300–400 A. They exhibited excellent magneto‐optical properties with a high coercive force about 1300 Oe and an effective Kerr angle of 1.5°. The crystallization process ...
10 citations
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27 Jun 2012
TL;DR: In this article, a heat resistance single-component silane modified polyurethane sealant and a preparation method for its preparation are presented. But the method is not suitable for the case of high temperature conditions.
Abstract: The invention relates to a heat resistance single-component silane modified polyurethane sealant and a preparation method thereof, which belong to the technical field of sealant. Use temperature of the existing silane modified polyurethane sealant all ranges from 0 to 100 DEG C, the existing silane modified polyurethane sealant can bear 120 DEG C for a short time, and a problem of remarkable mechanical property weakening exists if the existing silane modified polyurethane sealant is under a high temperature condition for a long time. The heat resistance single-component silane modified polyurethane sealant is mainly characterized by comprising (A) 30-40% Wt of silane modified polyurethane base polymer, (B) 30-45% Wt of filler, (C) 8-15% Wt of plasticizer, (D) 1-5% Wt of colorant, (E) 0.5-1% Wt of ultraviolet absorber, (F) 0.5-1% Wt of light stabilizer, (G) 0.4-1.5% Wt of heat resisting synergist, (H) 0.5-2% Wt of additive TI, (I) 0.5-2% Wt of silane coupling agent, (K) 0.5-2% Wt of thixtropic agent and (L) 0.2-1% Wt of catalyst. The heat resistance single-component silane modified polyurethane sealant has the advantages that heat resistance performance is greatly improved, and mechanical property after high-temperature ageing is kept well. The heat resistance single-component silane modified polyurethane sealant is mainly used in the industrial fields of automobile industry, railway transportation industry, and new energy industry and the like.
10 citations
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TL;DR: In this article , the authors proposed a parallel double-effect absorption power cycle using lithium bromide-water solution to make better use of the geothermal source, and the comprehensive energy, exergy, exergoeconomic and exerogoenvironmental models of this system are developed.
10 citations
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19 Apr 2022
TL;DR: This paper proposes a novel module named Feature Refinement Network (FRNet), which learns context-aware feature representations at bit-level for each feature in different contexts and can be applied in many existing methods to boost their performance.
Abstract: CTR prediction has been widely used in the real world. Many methods model feature interaction to improve their performance. However, most methods only learn a fixed representation for each feature without considering the varying importance of each feature under different contexts, resulting in inferior performance. Recently, several methods tried to learn vector-level weights for feature representations to address the fixed representation issue. However, they only produce linear transformations to refine the fixed feature representations, which are still not flexible enough to capture the varying importance of each feature under different contexts. In this paper, we propose a novel module named Feature Refinement Network (FRNet), which learns context-aware feature representations at bit-level for each feature in different contexts. FRNet consists of two key components: 1) Information Extraction Unit (IEU), which captures contextual information and cross-feature relationships to guide context-aware feature refinement; and 2) Complementary Selection Gate (CSGate), which adaptively integrates the original and complementary feature representations learned in IEU with bit-level weights. Notably, FRNet is orthogonal to existing CTR methods and thus can be applied in many existing methods to boost their performance. Comprehensive experiments are conducted to verify the effectiveness, efficiency, and compatibility of FRNet.
10 citations
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28,685 citations
28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。
18,940 citations
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TL;DR: In this article, a randomized controlled trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly people was presented. But the authors did not discuss the effect of the combination therapy in patients living with systolic hypertension.
Abstract: ABCD
: Appropriate Blood pressure Control in Diabetes
ABI
: ankle–brachial index
ABPM
: ambulatory blood pressure monitoring
ACCESS
: Acute Candesartan Cilexetil Therapy in Stroke Survival
ACCOMPLISH
: Avoiding Cardiovascular Events in Combination Therapy in Patients Living with Systolic Hypertension
ACCORD
: Action to Control Cardiovascular Risk in Diabetes
ACE
: angiotensin-converting enzyme
ACTIVE I
: Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events
ADVANCE
: Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation
AHEAD
: Action for HEAlth in Diabetes
ALLHAT
: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart ATtack
ALTITUDE
: ALiskiren Trial In Type 2 Diabetes Using Cardio-renal Endpoints
ANTIPAF
: ANgioTensin II Antagonist In Paroxysmal Atrial Fibrillation
APOLLO
: A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People
ARB
: angiotensin receptor blocker
ARIC
: Atherosclerosis Risk In Communities
ARR
: aldosterone renin ratio
ASCOT
: Anglo-Scandinavian Cardiac Outcomes Trial
ASCOT-LLA
: Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm
ASTRAL
: Angioplasty and STenting for Renal Artery Lesions
A-V
: atrioventricular
BB
: beta-blocker
BMI
: body mass index
BP
: blood pressure
BSA
: body surface area
CA
: calcium antagonist
CABG
: coronary artery bypass graft
CAPPP
: CAPtopril Prevention Project
CAPRAF
: CAndesartan in the Prevention of Relapsing Atrial Fibrillation
CHD
: coronary heart disease
CHHIPS
: Controlling Hypertension and Hypertension Immediately Post-Stroke
CKD
: chronic kidney disease
CKD-EPI
: Chronic Kidney Disease—EPIdemiology collaboration
CONVINCE
: Controlled ONset Verapamil INvestigation of CV Endpoints
CT
: computed tomography
CV
: cardiovascular
CVD
: cardiovascular disease
D
: diuretic
DASH
: Dietary Approaches to Stop Hypertension
DBP
: diastolic blood pressure
DCCT
: Diabetes Control and Complications Study
DIRECT
: DIabetic REtinopathy Candesartan Trials
DM
: diabetes mellitus
DPP-4
: dipeptidyl peptidase 4
EAS
: European Atherosclerosis Society
EASD
: European Association for the Study of Diabetes
ECG
: electrocardiogram
EF
: ejection fraction
eGFR
: estimated glomerular filtration rate
ELSA
: European Lacidipine Study on Atherosclerosis
ESC
: European Society of Cardiology
ESH
: European Society of Hypertension
ESRD
: end-stage renal disease
EXPLOR
: Amlodipine–Valsartan Combination Decreases Central Systolic Blood Pressure more Effectively than the Amlodipine–Atenolol Combination
FDA
: U.S. Food and Drug Administration
FEVER
: Felodipine EVent Reduction study
GISSI-AF
: Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Atrial Fibrillation
HbA1c
: glycated haemoglobin
HBPM
: home blood pressure monitoring
HOPE
: Heart Outcomes Prevention Evaluation
HOT
: Hypertension Optimal Treatment
HRT
: hormone replacement therapy
HT
: hypertension
HYVET
: HYpertension in the Very Elderly Trial
IMT
: intima-media thickness
I-PRESERVE
: Irbesartan in Heart Failure with Preserved Systolic Function
INTERHEART
: Effect of Potentially Modifiable Risk Factors associated with Myocardial Infarction in 52 Countries
INVEST
: INternational VErapamil SR/T Trandolapril
ISH
: Isolated systolic hypertension
JNC
: Joint National Committee
JUPITER
: Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin
LAVi
: left atrial volume index
LIFE
: Losartan Intervention For Endpoint Reduction in Hypertensives
LV
: left ventricle/left ventricular
LVH
: left ventricular hypertrophy
LVM
: left ventricular mass
MDRD
: Modification of Diet in Renal Disease
MRFIT
: Multiple Risk Factor Intervention Trial
MRI
: magnetic resonance imaging
NORDIL
: The Nordic Diltiazem Intervention study
OC
: oral contraceptive
OD
: organ damage
ONTARGET
: ONgoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial
PAD
: peripheral artery disease
PATHS
: Prevention And Treatment of Hypertension Study
PCI
: percutaneous coronary intervention
PPAR
: peroxisome proliferator-activated receptor
PREVEND
: Prevention of REnal and Vascular ENdstage Disease
PROFESS
: Prevention Regimen for Effectively Avoiding Secondary Strokes
PROGRESS
: Perindopril Protection Against Recurrent Stroke Study
PWV
: pulse wave velocity
QALY
: Quality adjusted life years
RAA
: renin-angiotensin-aldosterone
RAS
: renin-angiotensin system
RCT
: randomized controlled trials
RF
: risk factor
ROADMAP
: Randomized Olmesartan And Diabetes MicroAlbuminuria Prevention
SBP
: systolic blood pressure
SCAST
: Angiotensin-Receptor Blocker Candesartan for Treatment of Acute STroke
SCOPE
: Study on COgnition and Prognosis in the Elderly
SCORE
: Systematic COronary Risk Evaluation
SHEP
: Systolic Hypertension in the Elderly Program
STOP
: Swedish Trials in Old Patients with Hypertension
STOP-2
: The second Swedish Trial in Old Patients with Hypertension
SYSTCHINA
: SYSTolic Hypertension in the Elderly: Chinese trial
SYSTEUR
: SYSTolic Hypertension in Europe
TIA
: transient ischaemic attack
TOHP
: Trials Of Hypertension Prevention
TRANSCEND
: Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease
UKPDS
: United Kingdom Prospective Diabetes Study
VADT
: Veterans' Affairs Diabetes Trial
VALUE
: Valsartan Antihypertensive Long-term Use Evaluation
WHO
: World Health Organization
### 1.1 Principles
The 2013 guidelines on hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology …
14,173 citations
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TL;DR: This study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using CRISPR RNAs (crRNAs) to guide the silencing of invading nucleic acids. We show here that in a subset of these systems, the mature crRNA that is base-paired to trans-activating crRNA (tracrRNA) forms a two-RNA structure that directs the CRISPR-associated protein Cas9 to introduce double-stranded (ds) breaks in target DNA. At sites complementary to the crRNA-guide sequence, the Cas9 HNH nuclease domain cleaves the complementary strand, whereas the Cas9 RuvC-like domain cleaves the noncomplementary strand. The dual-tracrRNA:crRNA, when engineered as a single RNA chimera, also directs sequence-specific Cas9 dsDNA cleavage. Our study reveals a family of endonucleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the system for RNA-programmable genome editing.
12,865 citations