F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
Feng Zhang,Naomi Habib +1 more
TL;DR: In this paper, thermodynamic and multiplication methods concerning CRISPR-Cas systems, and apparatus therefor, have been discussed, and the thermodynamic properties of these systems have been investigated.
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Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum
TL;DR: In this article, the authors show that the Streptococcus pyogenes Cas9 DNA endonuclease and single guide RNAs (sgRNAs) produced using T7 RNA polymerase (T7 RNAP) efficiently edit the Plasmodium falciparum genome.
Journal ArticleDOI
Increased LIS1 expression affects human and mouse brain development
Weimin Bi,Tamar Sapir,Oleg A. Shchelochkov,Feng Zhang,Marjorie Withers,Jill V. Hunter,Talia Levy,Vera Shinder,Daniel A. Peiffer,Kevin L. Gunderson,Marjan M. Nezarati,Vern Ann Shotts,Stephen Amato,Sarah Savage,David J. Harris,Debra Day-Salvatore,Michele Horner,Xin Yan Lu,Trilochan Sahoo,Yuchio Yanagawa,Arthur L. Beaudet,Sau Wai Cheung,Salvador Martinez,James R. Lupski,Orly Reiner +24 more
TL;DR: It is shown that an increase in LIS1 expression in the developing brain results in brain abnormalities in mice and humans, and that increased PAFAH1B1 dosage causes mild brain structural abnormalities, moderate to severe developmental delay and failure to thrive.
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Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue
Jiayi Zhang,Farah Laiwalla,Jennifer A. Kim,Hayato Urabe,Rick Van Wagenen,Yoon-Kyu Song,Barry W. Connors,Feng Zhang,Karl Deisseroth,Arto V. Nurmikko +9 more
TL;DR: A novel dual-modality hybrid device, which consists of a tapered coaxial optical waveguide integrated into a 100 element intra-cortical multi-electrode recording array, is reported, which demonstrates the dual optical delivery and electrical recording capability of the single optrode in in vitro preparations of mouse retina.
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A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.
Hanneke J. M. Kerkhof,Rik Lories,Ingrid Meulenbelt,Ingileif Jonsdottir,Ana M. Valdes,Pascal P. Arp,Thorvaldur Ingvarsson,Mila Jhamai,Helgi Jonsson,Lisette Stolk,Gudmar Thorleifsson,Guangju Zhai,Feng Zhang,Yanyan Zhu,Ruud van der Breggen,Andrew Carr,Michael Doherty,Sally Doherty,David T. Felson,Antonio Gonzalez,Bjarni V. Halldorsson,Deborah J. Hart,Valdimar B. Hauksson,Albert Hofman,John P. A. Ioannidis,John P. A. Ioannidis,Margreet Kloppenburg,Nancy E Lane,John Loughlin,Frank P. Luyten,Michael C. Nevitt,Neeta Parimi,Huibert A. P. Pols,Fernando Rivadeneira,Eline Slagboom,Unnur Styrkarsdottir,Aspasia Tsezou,Tom Van de Putte,Joseph M. Zmuda,Tim D. Spector,Kari Stefansson,André G. Uitterlinden,Joyce B. J. van Meurs +42 more
TL;DR: A novel common variant on chromosome 7q22 that influences susceptibility to prevalence and progression of OA is identified, since the GPR22 gene encodes a G protein-coupled receptor, this is potentially an interesting therapeutic target.