F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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Journal ArticleDOI
Increasing frequencies of site-specific mutagenesis and gene targeting in Arabidopsis by manipulating DNA repair pathways
Yiping Qi,Yong Zhang,Yong Zhang,Feng Zhang,Joshua A. Baller,Spencer C. Cleland,Yungil Ryu,Colby G. Starker,Daniel F. Voytas +8 more
TL;DR: This study sought to enhance ZFN-mediated targeted mutagenesis and gene targeting in Arabidopsis by manipulating DNA repair pathways by analyzing repair outcomes in the absence of DNA repair proteins such as KU70 and LIG4.
Journal ArticleDOI
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells
Xiying Qu,Pengfei Wang,Donglin Ding,Lin Li,Hai Bo Wang,Li Ma,Xin Zhou,Shaohui Liu,Shiguan Lin,Xiaohui Wang,Gongmin Zhang,Sijie Liu,Lin Liu,Jian-Hua Wang,Feng Zhang,Daru Lu,Huanzhang Zhu +16 more
TL;DR: It is demonstrated that a single ZFN-LTR pair can specifically and effectively cleave integrated full-length HIV-1 proviral DNA and mediate antiretroviral activity in infected and latently infected cells, suggesting that this strategy could offer a novel approach to eradicate the HIV- 1 virus from the infected host in the future.
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Direct stacking of sequence-specific nuclease-induced mutations to produce high oleic and low linolenic soybean oil
Zachary L. Demorest,Andrew Coffman,Nicholas J. Baltes,Thomas Stoddard,Benjamin M. Clasen,Song Luo,Adam Retterath,Ann Yabandith,Maria Elena Gamo,Jeff Bissen,Luc Mathis,Daniel F. Voytas,Feng Zhang +12 more
TL;DR: The methods presented here provide an efficient means for using sequence-specific nucleases to stack quality traits in soybean and comprised oleic acid levels above 80 % and linoleic and linolenic Acid levels below 3 %.
Journal ArticleDOI
Assessing structural variation in a personal genome-towards a human reference diploid genome.
Adam C. English,William J Salerno,Oliver A. Hampton,Claudia Gonzaga-Jauregui,Shruthi Ambreth,Deborah I. Ritter,Christine R. Beck,Caleb F. Davis,Mahmoud Dahdouli,Singer Ma,Andrew Carroll,Narayanan Veeraraghavan,Jeremy Bruestle,Becky Drees,Alex Hastie,Ernest T. Lam,Simon D. M. White,Pamela Mishra,Min Wang,Yi Han,Feng Zhang,Pawel Stankiewicz,David A. Wheeler,Jeffrey G. Reid,Donna M. Muzny,Jeffrey Rogers,Aniko Sabo,Kim C. Worley,James R. Lupski,Eric Boerwinkle,Eric Boerwinkle,Richard A. Gibbs +31 more
TL;DR: Describing the SV content of a personal genome with Parliament, a publicly available consensus SV-calling infrastructure that merges multiple data types and SV detection methods, reveals the limits and advantages of multiple sequencing technologies, specifically the impact of long-read SV discovery.
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Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
Evangelos Evangelou,Ana M. Valdes,Hanneke J. M. Kerkhof,Unnur Styrkarsdottir,Yanyan Zhu,Ingrid Meulenbelt,Rik Lories,Fotini B. Karassa,Przemko Tylzanowski,Steffan D. Bos,Toru Akune,Nigel K Arden,Andrew Carr,Kay Chapman,L. Adrienne Cupples,Jin Dai,Panos Deloukas,Michael Doherty,Sally A Doherty,Gunnar Engström,Antonio Gonzalez,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Christina L. Hammond,Deborah J. Hart,Hafdis T. Helgadottir,Albert Hofman,Shiro Ikegawa,Thorvaldur Ingvarsson,Qing Jiang,Helgi Jonsson,Jaakko Kaprio,Hiroshi Kawaguchi,Kalle Kisand,Margreet Kloppenburg,Urho M. Kujala,L Stefan Lohmander,John Loughlin,Frank P. Luyten,Akihiko Mabuchi,Andrew McCaskie,Andrew McCaskie,Masahiro Nakajima,Peter M. Nilsson,Nao Nishida,William Ollier,Kalliope Panoutsopoulou,Tom Van de Putte,Stuart H. Ralston,F. Rivadeneira,Janna Saarela,Stefan Schulte-Merker,Dongquan Shi,P. Eline Slagboom,Akihiro Sudo,Agu Tamm,Ann Tamm,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Aspasia Tsezou,Gillian A. Wallis,J. Mark Wilkinson,Noriko Yoshimura,Eleftheria Zeggini,Eleftheria Zeggini,Guangju Zhai,Feng Zhang,Ingileif Jonsdottir,Ingileif Jonsdottir,André G. Uitterlinden,David T. Felson,Joyce B. J. van Meurs,Kari Stefansson,Kari Stefansson,John P. A. Ioannidis,Tim D. Spector +76 more
TL;DR: In this paper, a meta-analysis was performed of four genome-wide association (GWA) studies of 2371 cases of knee OA and 35 909 controls in Caucasian populations.