Feng Zhang

TL;DR: Bi-allelic mutations in TTC29, as an important genetic pathogeny, can induce MMAF-related asthenoteratospermia and provide effective guidance for clinical diagnosis and assisted reproduction treatments.

TL;DR: Zhang et al. as mentioned in this paper identified HSPC111 was the leading upregulated gene in hepatic stellate cells (HSCs) incubated with CRC cell-derived exosomes.

Abstract: CRISPR-Cas13 systems have been developed for precise RNA editing, and can potentially be used therapeutically when temporary changes are desirable or when DNA editing is challenging. We have identified and characterized an ultrasmall family of Cas13b proteins-Cas13bt-that can mediate mammalian transcript knockdown. We have engineered compact variants of REPAIR and RESCUE RNA editors by functionalizing Cas13bt with adenosine and cytosine deaminase domains, and demonstrated packaging of the editors within a single adeno-associated virus.

TL;DR: It is proposed that detecting co-existent CNVs when evaluating the association signals between SNPs and disease traits could improve genetic model analyses and better integrate GWAS with robust Mendelian principles.

TL;DR: In this article, structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the Cas complex, vectors and vector systems which encode one or more components or modified components, as well as methods for the design and use of such vectors and components.