F
Feng Zhang
Researcher at Fudan University
Publications - 2715
Citations - 225233
Feng Zhang is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 172, co-authored 1278 publications receiving 181865 citations. Previous affiliations of Feng Zhang include Cincinnati Children's Hospital Medical Center & Nanjing Medical University.
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High-resolution interrogation of functional elements in the noncoding genome
Neville E. Sanjana,Neville E. Sanjana,Jason Wright,Kaijie Zheng,Ophir Shalem,Pierre Fontanillas,Julia Joung,Christine S. Cheng,Aviv Regev,Feng Zhang +9 more
TL;DR: A large-scale CRISPR screen employing ~18,000 sgRNAs targeting >700 kb of noncoding sequence in an unbiased manner surrounding three genes involved in resistance to the BRAf inhibitor vemurafenib in the BRAF-mutant melanoma cell line A375 is developed.
Journal ArticleDOI
Artificial heart valves: improved hemocompatibility by titanium oxide coatings prepared by ion beam assisted deposition
Feng Zhang,Xianghuai Liu,Yingjun Mao,Nan Huang,Yu Chen,Zhihong Zheng,Zu-yao Zhou,Anqing Chen,Zhenbin Jiang +8 more
TL;DR: In this article, X-ray photoelectron spectroscopy (XPS), Rutherford backscattering spectroscopic (RBS) and Xray diffraction (XRD) were used to characterize the deposited titanium oxide films.
Journal ArticleDOI
Ex vivo induced regulatory T cells regulate inflammatory response of Kupffer cells by TGF-beta and attenuate liver ischemia reperfusion injury.
TL;DR: The results suggest that iTregs play a critical role in hepatic IRI by regulating pro-inflammatory and anti-inflammatory function of KCs through TGF-β.
Journal ArticleDOI
Optimization of multiplexed CRISPR/Cas9 system for highly efficient genome editing in Setaria viridis.
Trevor Weiss,Chunfang Wang,Xiaojun Kang,Hui Zhao,Maria Elena Gamo,Colby G. Starker,Peter A. Crisp,Peng Zhou,Nathan M. Springer,Daniel F. Voytas,Feng Zhang +10 more
TL;DR: A protoplast assay is developed to rapidly optimize the multiplexed CRISPR/Cas9 system in S. viridis in a rapid and high throughput manner, and has the potential to be widely applicable in achieving more predictable and deletion-only MMEJ-mediated mutations in many plant species.
Journal ArticleDOI
In vitro induced CD4(+)CD25(+)Foxp3(+) Tregs attenuate hepatic ischemia-reperfusion injury.
TL;DR: Tregs are investigated to pave the way to use Tregs as cell therapy to prevent hepatic I/R injury by preventing proinflammatory cytokines following a warm I-R insult.