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Fengling Zhu

Bio: Fengling Zhu is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: Molecularly imprinted polymer & Molecular imprinting. The author has an hindex of 1, co-authored 1 publications receiving 39 citations.

Papers
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Journal ArticleDOI
01 Apr 2016-Talanta
TL;DR: A novel dummy template molecularly imprinted polymer (DMIP) based on a vinyl-SiO2 microspheres surface for the simultaneous selective recognition and enrichment of 18 amino acids was prepared via a surface molecular imprinting technique using theanine as a dummy template, indicating that the obtained DMIP sorbents have high selectivity.

41 citations


Cited by
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Journal ArticleDOI
TL;DR: In this paper, the authors proposed the recent advances in molecular imprinting concerning novel preparation strategies of molecularly imprinted polymers (MIPs) and typical applications of MI-SPE.
Abstract: Molecular imprinting-based solid-phase extraction (MI-SPE) has been in the spotlight to improve the recognition selectivity and detection sensitivity. MI-SPE provides a powerful tool for chemo/bioanalysis in complex matrices and meanwhile, benefits from distinguished advantages such as easy operation, high throughput, low cost, high selectivity and durability. This review proposed the recent advances in molecular imprinting concerning novel preparation strategies of molecularly imprinted polymers (MIPs) and typical applications of MI-SPE. Preparation strategies are highlighted by dividing into ten sections mainly including dummy imprinting, multi-template imprinting, surface imprinting, water-compatible imprinting, restricted access material combining imprinting etc.; each section provides the descriptions about what restrictions led to the emergence of any strategy, strengths/weaknesses of every strategy and universal applications of upgraded MIPs in various SPE modes prior to chromatographic analysis. The potential of MIPs for implementation in routine laboratory activities and scale-up is expected, and finally remaining challenges and future perspectives are proposed.

278 citations

Journal ArticleDOI
TL;DR: In this paper, the dispersive-micro-solid phase extraction (D-μ-SPE) procedure based on a core-shell magnetic molecularly imprinted polymer (MMIP) in combination with high-performance liquid chromatography-ultraviolet (HPLC-UV) was developed for the preconcentration and determination of quercetin residues in Apium graveolens, Brassica oleracea, Spinacia olderacea, watercress, onion, and apple matrices.
Abstract: The objective of this study was to develop a simple, sensitive and selective procedure for the preconcentration and determination of quercetin residues in Apium graveolens, Brassica oleracea, Spinacia oleracea, watercress, onion, and apple matrices This novel method was developed on the basis of the dispersive-micro-solid phase extraction (D-μ-SPE) procedure based on a core–shell magnetic molecularly imprinted polymer (MMIP) in combination with high-performance liquid chromatography-ultraviolet (HPLC-UV) Variables affecting the quercetin extraction efficiency included pH, MIP dose, extraction contact time, elution organic solvent, and volume of organic solvent and were evaluated by the experimental central composite design (CCD) The obtained optimal parameters were as follows: pH (35), sorbent (12 mg), elution organic solvent and solvent volume (methanol, 02 mL), and elution time (220 min, without adding salt) The calibration curve was linear in the concentration range of 06–5500 μg L−1 with the lower limits of detection found in the range of 0113–0117 μg L−1, thereby revealing the high-sensitivity and -selectivity properties The combination of D-μ-SPE and HPLC-UV could provide a method for the recovery of the analyte in various matrices at 22 min contact time with good reusability and excellent recoveries at four concentration levels (50, 100, 500, and 1000 μg L−1), ranging between 9544 and 10689% (relative standard deviation <60%) Based on competitive sorption experiments, the synthesized MMIP displays higher selectivity toward quercetin compared to non-imprinted polymers (NIPs) and other sorbents

76 citations

Journal ArticleDOI
TL;DR: In this review, the characteristics, morphologies, and applicability of currently popular carrier materials for molecular imprinting, especially the fundamental role of hydrogels, porous materials, hierarchical nanoparticles, and 2D materials in the separation and recognition of biological templates are discussed.
Abstract: Molecular imprinting is an approach of generating imprinting cavities in polymer structures that are compatible with the target molecules. The cavities have memory for shape and chemical recognition, similar to the recognition mechanism of antigen-antibody in organisms. Their structures are also called biomimetic receptors or synthetic receptors. Owing to the excellent selectivity and unique structural predictability of molecularly imprinted materials (MIMs), practical MIMs have become a rapidly evolving research area providing key factors for understanding separation, recognition, and regenerative properties toward biological small molecules to biomacromolecules, even cell and microorganism. In this review, the characteristics, morphologies, and applicability of currently popular carrier materials for molecular imprinting, especially the fundamental role of hydrogels, porous materials, hierarchical nanoparticles, and 2D materials in the separation and recognition of biological templates are discussed. Moreover, through a series of case studies, emphasis is given on introducing imprinting strategies for biological templates with different molecular scales. In particular, the differences and connections between small molecular imprinting (bulk imprinting, "dummy" template imprinting, etc.), large molecular imprinting (surface imprinting, interfacial imprinting, etc.), and cell imprinting strategies are demonstrated in detail. Finally, future research directions are provided.

69 citations

Journal ArticleDOI
01 Aug 2017-Talanta
TL;DR: Results indicated that amphiphilic MMIPs were the promising sorbents for the selective enrichment of chloroacetamide herbicides at trace levels from real environmental water samples.

63 citations

Journal ArticleDOI
TL;DR: This is the first study reporting the use of molecularly imprinted polymer-based method for determination of phenothiazines residues in foods by using computational simulation method and solid phase extraction column.

48 citations