Ferenc Müller

TL;DR: It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity.

TL;DR: This work mapped and examined the function of human islet cis-regulatory networks and identifies genomic sequences that are targeted by islet transcription factors to drive islet-specific gene activity and shows that most such sequences reside in clusters of enhancers that form physical three-dimensional chromatin domains.

TL;DR: It is proposed, that the transcription compartment is part of the regulatory architecture of embryonic nuclei and offers a transcriptionally competent environment to facilitate early escape from repression before global genome activation.

TL;DR: The zebrafish could therefore be used as cost-effective and ethically acceptable animal models for drug screening as well as toxicity testing, and appears to outplay the traditional rodent models of toxicity testing.

TL;DR: Observations suggest that DIS3L2 has a critical role in RNA metabolism and is essential for the regulation of cell growth and division.