Author
Fergal J. O'Brien
Other affiliations: Trinity College, Dublin, University College Dublin, Massachusetts Institute of Technology ...read more
Bio: Fergal J. O'Brien is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Tissue engineering & Mesenchymal stem cell. The author has an hindex of 75, co-authored 317 publications receiving 20104 citations. Previous affiliations of Fergal J. O'Brien include Trinity College, Dublin & University College Dublin.
Papers published on a yearly basis
Papers
More filters
TL;DR: The functional requirements, and types, of materials used in developing state of the art of scaffolds for tissue engineering applications are described and where future research and direction is required are described.
2,648 citations
TL;DR: The results show that cell number was highest in scaffolds with the largest pore size, which was deemed optimal for bone tissue engineering, and an added advantage of the larger pores is a reduction in cell aggregations that develop along the edges of the scaffolds.
1,631 citations
TL;DR: The strong correlation between the scaffoldspecific surface area and cell attachment indicates that cell attachment and viability are primarily influenced by scaffold specific surface area over this range (95.9-150.5 microm) of pore sizes for MC3T3 cells.
1,219 citations
TL;DR: The scaffold synthesis process was modified to produce more homogeneous freezing by controlling of the rate of freezing during fabrication and obtaining more uniform contact between the pan containing the CG suspension and the freezing shelf through the use of smaller, less warped pans.
736 citations
TL;DR: An in depth understanding of biomaterial cues to selectively polarize macrophages may prove beneficial in the design of a new generation of ‘immuno-informed’ biomaterials that can positively interact with the immune system to dictate a favorable macrophage response following implantation.
617 citations
Cited by
More filters
Journal Article•
28,685 citations
TL;DR: The functional requirements, and types, of materials used in developing state of the art of scaffolds for tissue engineering applications are described and where future research and direction is required are described.
2,648 citations
TL;DR: This Review discusses how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation, and collects experimental release data from the literature and presents quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
Abstract: Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel-drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
2,457 citations
TL;DR: In this paper, the basic principles involved in designing hierarchical biological materials, such as cellular and composite architectures, adapative growth and as well as remodeling, are discussed, and examples that are found to utilize these strategies include wood, bone, tendon, and glass sponges.
2,274 citations