F
Fernanda I. Saldívar-González
Researcher at National Autonomous University of Mexico
Publications - 19
Citations - 382
Fernanda I. Saldívar-González is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Cheminformatics & Chemical space. The author has an hindex of 10, co-authored 15 publications receiving 226 citations.
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Journal ArticleDOI
BIOFACQUIM: A Mexican Compound Database of Natural Products
B. Angélica Pilón-Jiménez,Fernanda I. Saldívar-González,Bárbara I. Díaz-Eufracio,José L. Medina-Franco +3 more
TL;DR: This proof-of-concept study discusses the first version of BIOFACQUIM, a novel compound database with natural products isolated and characterized in Mexico, and discusses its construction, curation, and a complete chemoinformatic characterization of the content and coverage in chemical space.
Journal ArticleDOI
Chemical Space and Diversity of the NuBBE Database: A Chemoinformatic Characterization.
Fernanda I. Saldívar-González,Marilia Valli,Adriano D. Andricopulo,Vanderlan da Silva Bolzani,José L. Medina-Franco +4 more
TL;DR: A comprehensive chemoinformatic analysis of the most current version of NuBBEDB showed that NUBBEDB is a promising source of molecules for drug discovery and medicinal chemistry.
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Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective.
Fernanda I. Saldívar-González,Alejandro Gómez-García,David E. Chávez-Ponce de León,Norberto Sánchez-Cruz,Javier Ruiz-Rios,B. Angélica Pilón-Jiménez,José L. Medina-Franco +6 more
TL;DR: The chemoinformatic-guided exploration of the chemical space of naturally occurring compounds as epigenetic modulators which may have significant implications in epigenetic drug discovery and nutriepigenetics are discussed.
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Ivermectin as an inhibitor of cancer stem‑like cells.
Guadalupe Domínguez-Gómez,Alma Chavez-Blanco,José L. Medina-Franco,Fernanda I. Saldívar-González,Ytzel Flores-Torrontegui,Mandy Juarez,José Díaz-Chávez,Aurora Gonzalez-Fierro,Alfonso Dueñas-González +8 more
TL;DR: Ivermectin preferentially inhibited the CSC subpopulation in the MDA‑MB‑231 cells and downregulated the expression of genes involved in the maintenance of pluripotency and self‑renewal.
Journal ArticleDOI
Exploring the chemical space and the bioactivity profile of lactams: a chemoinformatic study
TL;DR: Results of the biological and chemoinformatic analysis of lactams indicate that spiro- and bridged-lactams belong to classes with the lowest number of compounds and unique scaffolds, and some showing activity against specific targets.