Fernando Albericio

Bio: Fernando Albericio is an academic researcher from University of KwaZulu-Natal. The author has contributed to research in topics: Peptide synthesis & Solid-phase synthesis. The author has an hindex of 76, co-authored 965 publications receiving 26146 citations. Previous affiliations of Fernando Albericio include University of Barcelona & University of Chile.

Peptide coupling reagents, more than a letter soup

Abstract: Peptide Coupling Reagents, More than a Letter Soup Ayman El-Faham* and Fernando Albericio* Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain Alexandria University, Faculty of Science, Department of Chemistry, P.O. Box 426, Ibrahimia, 21321 Alexandria, Egypt CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. Department of Organic Chemistry, University of Barcelona, Martí i Franqu es 1-11, 08028-Barcelona, Spain

Amino Acid-Protecting Groups

Abstract: Albert Isidro-Llobet, Mercedes Alvarez,* and Fernando Albericio* Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain; CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain; Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain; and Department of Organic Chemistry, University of Barcelona, Marti i Franques 1, 08028 Barcelona, Spain Received April 28, 2008

Chemical Approaches to the Synthesis of Peptides and Proteins

Abstract: Introduction Amino Acids and Peptide and Protein Structure Amino Acid Activation and Coupling Protection Schemes for Peptide Synthesis The Synthesis of Peptides Solid-Phase Peptide Synthesis The Solid Support Protection Schemes Attachment of the First Amino Acid to the Solid Support Chain Elongation Cleavage of the Peptide from the Resin Examples of Protein Synthesis by Linear SPPS Peptide Synthesis in Solution Strategic Considerations Protection Schemes Chain Elongation Final Removal of Protecting Groups Special Approaches to the Synthesis of Peptides in Solution Examples of Peptide Synthesis in Solution Convergent Approaches to the Synthesis of Large Peptides and Proteins Convergent Solid-Phase Peptide Synthesis The Coupling of Protected Peptide Segments in Solution Coupling of Minimally Protected Peptides in Aqueous Solution Chemical Ligation of Peptide Segments Formation of Disulfide Bridges Peptides with Disulfide Bridges Protection of Cysteine in Peptide Synthesis Chemical Methods for the Formation of Disulfide Bridges Regioselective Disulfide Bridge Formation Peptide Libraries Multiple Peptide Synthesis in Parallel Peptide Library Techniques Examples of Peptide Library Synthesisi Each chapter contains References

Structure, Bioactivity and Synthesis of Natural Products with Hexahydropyrrolo[2,3‐b]indole

Abstract: Research on natural products containing hexahydropyrrolo[2,3-b]indole (HPI) has dramatically increased during the past few years. Newly discovered natural products with complex structures and important biological activities have recently been isolated and synthesized. This review summarizes the structures, biological activities, and synthetic routes for natural compounds containing HPI, emphasizing the different strategies for assembling this motif. It covers a broad range of molecules, from small alkaloids to complex peptides.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

Phd by thesis

Abstract: Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These