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Fernando Rodríguez Artalejo

Other affiliations: Carlos III Health Institute
Bio: Fernando Rodríguez Artalejo is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Body mass index & Population. The author has an hindex of 18, co-authored 57 publications receiving 2025 citations. Previous affiliations of Fernando Rodríguez Artalejo include Carlos III Health Institute.


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TL;DR: There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions, however, additional research is needed before an operative definition of frailty can be established.
Abstract: BACKGROUND: There is no consensus regarding the definition of frailty for clinical uses. METHODS: A modified Delphi process was used to attempt to achieve consensus definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire was developed and sent to experts in the area of frailty. Responses and comments were analyzed using a pre-established strategy. Statements with an agreement more than or equal to 80% were accepted. RESULTS: Overall, 44% of the statements regarding the concept of frailty and 18% of the statements regarding diagnostic criteria were accepted. There was consensus on the value of screening for frailty and about the identification of six domains of frailty for inclusion in a clinical definition, but no agreement was reached concerning a specific set of clinical/laboratory biomarkers useful for diagnosis. CONCLUSIONS: There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions. However, additional research is needed before an operative definition of frailty can be established.

929 citations

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TL;DR: The inversion of the relationship between SES and IHD, and the increase in socioeconomic differences in IHD in recent years suggest that the problem is potentially controllable and that the necessary policies should be implemented as a matter of urgency.
Abstract: Methods A systematic review was conducted into the relationship between SES and IHD, as reported by cohort and case-control studies in which SES had been measured by education or occupation. A bibliographic search, covering the period 19601993, was carried out using Index Medicus, MEDLTNE, Sociological Abstracts, Social Scisearch and the references cited in papers identified in such databases. Finally, 34 studies were selected, with data being extracted separately by two reviewers working independently. Where differences of opinion arose, these were resolved by discussion between the two. Multiple linear regression analysis was used to identify determinants of inter-study heterogeneity. Results Risk of IHD was inversely related to educational level in the period 1982-1993. There was a lower risk of IHD among manual workers versus non-manual workers until approximately 1970; thereafter the relationship became inverted. The odds ratio for IHD in manual workers rose progressively over the period 1960-1993, something that could not be explained by study design, study size, study country or control for confounding factors. Education- and occupationrelated differences in risk of IHD affected all SES levels. Conclusions These findings agree with those yielded by ecological, cross-sectional and longitudinal mortality studies, although they cannot be extrapolated to women, nonwhite ethnic groups, or developing countries. The inversion of the relationship between SES and IHD, and the increase in socioeconomic differences in IHD in recent years suggest that the problem is potentially controllable and that the necessary policies should be implemented as a matter of urgency. Ischaemic heart disease, socioeconomic status, education, occupation, systematic review

146 citations

Journal ArticleDOI
20 Jan 2014-PLOS ONE
TL;DR: The DH-E shows good validity and reproducibility for estimating usual intake of foods and nutrients, and the intraclass correlation coefficient between the twoDH-E was greater than 0.40 for most food and nutrients.
Abstract: Specific funding for this work was obtained from ‘Fondo de Investigacines Sanitarias’ (FIS) grant PI08/0166

139 citations

Journal ArticleDOI
TL;DR: The results raise questions about the association between WRPA and obesity and suggest the need to reexamine models of the obesity epidemic that point to automation of the workplace as one of the major explanatory factors.
Abstract: Objective: To analyze the association of work-related physical activity (WRPA) and leisure-time physical activity (LTPA) with body mass index (BMI) and obesity in the Spanish adult population aged 20 to 60 years. Research Methods and Procedures: The data were taken from the 1993 Spanish National Health Survey. We analyzed a sample of 12,044 men and women representative of the Spanish population aged 20 to 60 years. BMI and frequency of obesity (BMI ≥ 30 kg/m2) were obtained from self-reported weight and height. Multiple linear regression and logistic regression models were constructed, adjusting for the main confounding factors. WRPA and LTPA were measured by two questions to classify subjects into four categories of physical activity. Results: Neither mean BMI nor percentage of obesity varied significantly (p > 0.05) by WRPA. Mean BMI was significantly higher (p < 0.01) in those who were inactive in their leisure time (25.90 kg/m2 in men and 24.43 kg/m2 in women) than in those who reported vigorous activity (24.42 kg/m2 and 22.97 kg/m2 in men and women, respectively). The odds ration (OR) for obesity decreased with increasing level of LTPA in both men (OR of 0.64 for vigorous activity) and women (OR = 0.68), showing a statistically significant dose-response relation in both men (for linear trend, p = 0.0021) and women (p = 0.0245). Discussion: These results raise questions about the association between WRPA and obesity and suggest the need to reexamine models of the obesity epidemic that point to automation of the workplace as one of the major explanatory factors.

109 citations

Journal ArticleDOI
TL;DR: In 2000, Basandose et al. as discussed by the authors present a documento "Control de the Colesterolemia en Espana, 2000: Un instrumento para la Prevencion Cardiovascular", which revisa evidencia existente en el campo de la prevencione cardiovascular and the avances terapeuticos producidos in the ultimas anos, con el objetivo de ayudar a tomar decisiones clinicas basadas en el riesgo cardiovascular.
Abstract: El documento «Control de la Colesterolemia en Espana, 2000: Un instrumento para la Prevencion Cardiovascular » revisa la evidencia existente en el campo de la prevencion cardiovascular y los avances terapeuticos producidos en los ultimos anos, con el objetivo de ayudar a tomar decisiones clinicas basadas en el riesgo cardiovascular Las enfermedades cardiovasculares son la primera causa de muerte en Espana Su impacto demografico, sanitario y social esta aumentando y va a continuar haciendolo en las proximas decadas El adecuado tratamiento de la hipercolesterolemia y del resto de los factores de riesgo es fundamental para prevenir las enfermedades cardiovasculares La estratificacion del riesgo de las personas es esencial, por cuanto condiciona la periodicidad del seguimiento y la indicacion e intensidad del tratamiento Basandose en dicha estratificacion se han establecido unas prioridades de control de la colesterolemia y del riesgo cardiovascular derivado de la misma En prevencion primaria en los pacientes de riesgo alto, el objetivo terapeutico se establece en un cLDL inferior a 130 mg/dl En prevencion secundaria, el tratamiento farmacologico se instaurara con un cLDL ≥ 130 mg/dl y el objetivo terapeutico sera cLDL Las estatinas son los farmacos de primera eleccion en el tratamiento de la hipercolesterolemia Cuando exista hipertrigliceridemia moderada-grave y cHDL bajo se emplearan los fibratos En el sindrome coronario agudo, el tratamiento hipolipemiante, cuando este indicado, debe iniciarse precozmente

107 citations


Cited by
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TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
Abstract: ABI : ankle–brachial index ACCORD : Action to Control Cardiovascular Risk in Diabetes ADVANCE : Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation AGREE : Appraisal of Guidelines Research and Evaluation AHA : American Heart Association apoA1 : apolipoprotein A1 apoB : apolipoprotein B CABG : coronary artery bypass graft surgery CARDS : Collaborative AtoRvastatin Diabetes Study CCNAP : Council on Cardiovascular Nursing and Allied Professions CHARISMA : Clopidogrel for High Athero-thrombotic Risk and Ischemic Stabilisation, Management, and Avoidance CHD : coronary heart disease CKD : chronic kidney disease COMMIT : Clopidogrel and Metoprolol in Myocardial Infarction Trial CRP : C-reactive protein CURE : Clopidogrel in Unstable Angina to Prevent Recurrent Events CVD : cardiovascular disease DALYs : disability-adjusted life years DBP : diastolic blood pressure DCCT : Diabetes Control and Complications Trial ED : erectile dysfunction eGFR : estimated glomerular filtration rate EHN : European Heart Network EPIC : European Prospective Investigation into Cancer and Nutrition EUROASPIRE : European Action on Secondary and Primary Prevention through Intervention to Reduce Events GFR : glomerular filtration rate GOSPEL : Global Secondary Prevention Strategies to Limit Event Recurrence After MI GRADE : Grading of Recommendations Assessment, Development and Evaluation HbA1c : glycated haemoglobin HDL : high-density lipoprotein HF-ACTION : Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing HOT : Hypertension Optimal Treatment Study HPS : Heart Protection Study HR : hazard ratio hsCRP : high-sensitivity C-reactive protein HYVET : Hypertension in the Very Elderly Trial ICD : International Classification of Diseases IMT : intima-media thickness INVEST : International Verapamil SR/Trandolapril JTF : Joint Task Force LDL : low-density lipoprotein Lp(a) : lipoprotein(a) LpPLA2 : lipoprotein-associated phospholipase 2 LVH : left ventricular hypertrophy MATCH : Management of Atherothrombosis with Clopidogrel in High-risk Patients with Recent Transient Ischaemic Attack or Ischaemic Stroke MDRD : Modification of Diet in Renal Disease MET : metabolic equivalent MONICA : Multinational MONItoring of trends and determinants in CArdiovascular disease NICE : National Institute of Health and Clinical Excellence NRT : nicotine replacement therapy NSTEMI : non-ST elevation myocardial infarction ONTARGET : Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial OSA : obstructive sleep apnoea PAD : peripheral artery disease PCI : percutaneous coronary intervention PROactive : Prospective Pioglitazone Clinical Trial in Macrovascular Events PWV : pulse wave velocity QOF : Quality and Outcomes Framework RCT : randomized clinical trial RR : relative risk SBP : systolic blood pressure SCORE : Systematic Coronary Risk Evaluation Project SEARCH : Study of the Effectiveness of Additional Reductions in Cholesterol and SHEP : Systolic Hypertension in the Elderly Program STEMI : ST-elevation myocardial infarction SU.FOL.OM3 : SUpplementation with FOlate, vitamin B6 and B12 and/or OMega-3 fatty acids Syst-Eur : Systolic Hypertension in Europe TNT : Treating to New Targets UKPDS : United Kingdom Prospective Diabetes Study VADT : Veterans Affairs Diabetes Trial VALUE : Valsartan Antihypertensive Long-term Use VITATOPS : VITAmins TO Prevent Stroke VLDL : very low-density lipoprotein WHO : World Health Organization ### 1.1 Introduction Atherosclerotic cardiovascular disease (CVD) is a chronic disorder developing insidiously throughout life and usually progressing to an advanced stage by the time symptoms occur. It remains the major cause of premature death in Europe, even though CVD mortality has …

7,482 citations

Journal ArticleDOI
TL;DR: ABI is ankle-brachial (blood pressure) index and ABPM is ambulatory blood pressure monitoring as mentioned in this paper ; ACCORD is action to control cardiovascular risk in Diabetes and Vascular disease.
Abstract: ABI : ankle–brachial (blood pressure) index ABPM : ambulatory blood pressure monitoring ACCORD : Action to Control Cardiovascular Risk in Diabetes ACE-I : angiotensin-converting enzyme inhibitor ACS : acute coronary syndromes ADVANCE : Action in Diabetes and Vascular disease: PreterAx

4,352 citations

Journal ArticleDOI
TL;DR: Authors/Task Force Members: Massimo F. Piepoli (Chairperson), Arno W. Hoes (Co-Chairperson) (The Netherlands), Stefan Agewall (Norway) 1, Christian Albus (Germany)9, Carlos Brotons (Spain)10, Alberico L. Catapano (Italy)3, Marie-Therese Cooney (Ireland)1, Ugo Corrà (Italy).
Abstract: Authors/Task Force Members: Massimo F. Piepoli* (Chairperson) (Italy), Arno W. Hoes* (Co-Chairperson) (The Netherlands), Stefan Agewall (Norway)1, Christian Albus (Germany)9, Carlos Brotons (Spain)10, Alberico L. Catapano (Italy)3, Marie-Therese Cooney (Ireland)1, Ugo Corrà (Italy)1, Bernard Cosyns (Belgium)1, Christi Deaton (UK)1, Ian Graham (Ireland)1, Michael Stephen Hall (UK)7, F. D. Richard Hobbs (UK)10, Maja-Lisa Løchen (Norway)1, Herbert Löllgen (Germany)8, Pedro Marques-Vidal (Switzerland)1, Joep Perk (Sweden)1, Eva Prescott (Denmark)1, Josep Redon (Spain)5, Dimitrios J. Richter (Greece)1, Naveed Sattar (UK)2, Yvo Smulders (The Netherlands)1, Monica Tiberi (Italy)1, H. Bart van der Worp (The Netherlands)6, Ineke van Dis (The Netherlands)4, W. M. Monique Verschuren (The Netherlands)1

2,189 citations

Journal ArticleDOI
TL;DR: Results underscore a view of obesity as a social phenomenon, for which appropriate action includes targeting both economic and sociocultural factors.
Abstract: The objective of this review was to update Sobal and Stunkard’s exhaustive review of the literature on the relation between socioeconomic status (SES) and obesity (Psychol Bull 1989;105:260–75). Diverse research databases (including CINAHL, ERIC, MEDLINE, and Social Science Abstracts) were comprehensively searched during the years 1988–2004 inclusive, using ‘‘obesity,’’ ‘‘socioeconomic status,’’ and synonyms as search terms. A total of 333 published studies, representing 1,914 primarily cross-sectional associations, were included in the review. The overall pattern of results, for both men and women, was of an increasing proportion of positive associations and a decreasing proportion of negative associations as one moved from countries with high levels of socioeconomic development to countries with medium and low levels of development. Findings varied by SES indicator; for example, negative associations (lower SES associated with larger body size) for women in highly developed countries were most common with education and occupation, while positive associations for women in medium- and low-development countries were most common with income and material possessions. Patterns for women in higher- versus lower-development countries were generally less striking than those observed by Sobal and Stunkard; this finding is interpreted in light of trends related to globalization. Results underscore a view of obesity as a social phenomenon, for which appropriate action includes targeting both economic and sociocultural factors.

1,989 citations