F
Finn Bauer
Researcher at University of Erlangen-Nuremberg
Publications - 11
Citations - 654
Finn Bauer is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: SH3 domain & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 10, co-authored 11 publications receiving 625 citations. Previous affiliations of Finn Bauer include University of Bayreuth & University of Oxford.
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Journal ArticleDOI
Structure Determination of Human and Murine Beta-Defensins Reveals Structural Conservation in the Absence of Significant Sequence Similarity
Finn Bauer,Kristian Schweimer,Enno Klüver,Jose-Ramon Conejo-Garcia,Wolf-Georg Forssmann,Paul Rösch,Knut Adermann,Heinrich Sticht +7 more
TL;DR: It is significant that β‐defensins do not exhibit a common pattern of charged and hydrophobic residues on the protein surface and that the β‐ defensin‐specific fold appears to accommodate a wide range of different amino acids at most sequence positions.
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The T-cell Lymphokine Interleukin-26 Targets Epithelial Cells through the Interleukin-20 Receptor 1 and Interleukin-10 Receptor 2 Chains
Simon Hör,Simon Hör,Heide Pirzer,Laure Dumoutier,Finn Bauer,Sabine Wittmann,Heinrich Sticht,Jean-Christophe Renauld,Rene de Waal Malefyt,Helmut Fickenscher +9 more
TL;DR: Targeting epithelial cells, the T-cell lymphokine IL-26 is likely to play a role in local mechanisms of mucosal and cutaneous immunity.
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Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.
Alejandro Leal,Kathrin Huehne,Finn Bauer,Heinrich Sticht,Philipp Berger,Ueli Suter,Bernal Morera,Gerardo Del Valle,James R. Lupski,Arif B. Ekici,Francesca Pasutto,Sabine Endele,Ramiro Barrantes,Corinna Berghoff,Martin Berghoff,Bernhard Neundörfer,D. Heuss,Thomas Dorn,Peter Young,Lisa Santolin,Thomas Uhlmann,Michael Meisterernst,Michael W. Sereda,Ruth M. Stassart,Gerd Meyer zu Hörste,Klaus-Armin Nave,André Reis,Bernd Rautenstrauss +27 more
TL;DR: A homozygous p.A335V mutation in the MED25 gene in an extended Costa Rican family with autosomal recessively inherited Charcot-Marie-Tooth neuropathy is identified and a potential role of this protein in the molecular etiology of CMT2B2 is suggested.
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Structural Investigation of the Binding of a Herpesviral Protein to the SH3 Domain of Tyrosine Kinase Lck
Kristian Schweimer,Silke Hoffmann,Finn Bauer,Ute Friedrich,Christian Kardinal,Stephan M. Feller,Brigitte Biesinger,Heinrich Sticht +7 more
TL;DR: Fluorescence spectroscopy shows that Tip binds to the SH3 domains of several Src kinases (Lck, Hck, Lyn, Src, Fyn, Yes), exhibiting the highest affinities for Lyn, Hock, and Lck.
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Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs.
TL;DR: Results suggest that in vivo, too, competition between Lck-SH3 homodimerization and binding of regulatory proline-rich sequence motifs possibly represents a novel mechanism by which kinase activity is modulated.