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Author

Flávio Fernando Demarco

Other affiliations: University of Michigan
Bio: Flávio Fernando Demarco is an academic researcher from Universidade Federal de Pelotas. The author has contributed to research in topics: Medicine & Cohort study. The author has an hindex of 48, co-authored 340 publications receiving 9128 citations. Previous affiliations of Flávio Fernando Demarco include University of Michigan.


Papers
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TL;DR: A long survival rate for posterior composite restorations can be expected provided that patient, operator and materials factors are taken into account when the restorATIONS are performed.

762 citations

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TL;DR: In this paper, the authors investigated the longevity of posterior restorations placed in a single general practice using two different composites in filler characteristics and material properties: P-50 APC (3M ESPE) with 70vol.% inorganic filler loading (midfilled) and Herculite XR (Kerr) with 55vol.%.

281 citations

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TL;DR: The clinical performance of posterior resin composite restorations evaluated was acceptable after 17-year evaluation, however, the probability of failure of resin composite Restorations in molars, Class II, and large restorATIONS is higher.

267 citations

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TL;DR: Fracture of tooth/restoration was the most common reason for failure, whereas failures related to aesthetic qualities were more frequent when restorations were placed for aesthetic reasons.

243 citations

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TL;DR: It is demonstrated that dentin-derived BMP-2 is required to induce the differentiation of SHED into odontoblastic differentiation by SHED cultured in tooth slice/scaffolds.
Abstract: It is known that stem cells from exfoliated deciduous teeth (SHED) can be induced to differentiate into odontoblasts. However, the nature of dentin-derived morphogenic signals required for dental pulp stem cell differentiation remains unclear. The hypothesis underlying this work is that dentin-derived Bone Morphogenetic Proteins (BMP) are necessary for the differentiation of SHED into odontoblasts. We observed that SHED express markers of odontoblastic differentiation (DSPP, DMP-1, MEPE) when seeded in human tooth slice/scaffolds and cultured in vitro, or implanted subcutaneously into immunodeficient mice. In contrast, SHED cultured in deproteinized tooth slice/scaffolds, or scaffolds without a tooth slice, do not express these markers. SHED express the BMP receptors BMPR-IA, BMPR-IB, and BMPR-II. Notably, blockade of BMP-2 signaling inhibited the expression of markers of odontoblastic differentiation by SHED cultured in tooth slice/scaffolds. Collectively, this work demonstrates that dentin-derived BMP-2 is required to induce the differentiation of SHED into odontoblasts.

236 citations


Cited by
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TL;DR: There is no one ideal material available to the clinician, but the commercial materials that comprise the current armamentarium are of high quality and when used appropriately, have proven to deliver excellent clinical outcomes of adequate longevity.

1,525 citations

Journal ArticleDOI
TL;DR: MTA is a bioactive material that influences its surrounding environment and possesses some antibacterial and antifungal properties, depending on its powder-to-liquid ratio.

1,019 citations

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TL;DR: On the basis of available evidence it appears that MTA seals well and is a biocompatible material.

810 citations