Author
Fleming Martínez
Other affiliations: University of Alcalá
Bio: Fleming Martínez is an academic researcher from National University of Colombia. The author has contributed to research in topics: Solubility & Solvation. The author has an hindex of 41, co-authored 366 publications receiving 6533 citations. Previous affiliations of Fleming Martínez include University of Alcalá.
Topics: Solubility, Solvation, Enthalpy, Gibbs free energy, Dissolution
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the solubility of indomethacin (IMC) in 1,4-dioxane+water cosolvent mixtures was determined at several temperatures, 293.15-313.15 K. The authors used van't Hoff and Gibbs equations to obtain the thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and of mixing.
287 citations
TL;DR: In this paper, the solubility of carvedilol in ethanol and propylene glycol mixtures at various temperatures was investigated and the results showed that carvedilols are solubile in both types of mixtures.
Abstract: Article on the solubility of carvedilol in ethanol and propylene glycol mixtures at various temperatures.
200 citations
TL;DR: In this article, the van't Hoff and Gibbs equations were used to evaluate the solubility of ketoprofen in propylene glycol+water (PG+W) cosolvent mixtures.
154 citations
TL;DR: In this paper, the results of numerical analyses performed by Dali et al. on their experimental solubility of gallic acid in aqueous mixtures of acetonitrile, 1-propanol and 2-pro panol at different temperatures, in terms of the data modeling according to the Jouyban-Acree model and also the evaluation of the preferential solvation of this compound by organic solvents and water in the saturated mixtures based on the inverse Kirkwood-Buff integrals.
130 citations
TL;DR: In this article, the authors measured the solubility of indomethacin at several temperatures (20-40°C) at the polarity range provided by aqueous (ethanol-water, solubile parameter δM = 26.51-47.97
130 citations
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TL;DR: The Merck Index of Chemicals and Drugs is an encyclopedia for the Chemist, Pharmacist, Physician and Allied Professions and thumb-indexed, 8 dollars.
Abstract: The Merck Index of Chemicals and Drugs An Encyclopedia for the Chemist, Pharmacist, Physician and Allied Professions Sixth edition Pp xiv + 1167 (Rahway, NJ: Merck and Company, Inc, 1952) 750 dollars; thumb-indexed, 8 dollars
972 citations
TL;DR: Results suggest that the unique physiochemical properties of ILs in general, may confer a novel effect for the bioactivity of an API due to (at least) slow-release properties in addition to novel delivery mechanisms.
Abstract: A modular, ionic liquid (IL)-based strategy allows compartmentalized molecular level design of a wide range of new materials with tunable biological, as well as the well known physical and chemical, properties of ILs, which thus deserve consideration as ‘tunable’ active pharmaceutical ingredients (APIs) with novel performance enhancement and delivery options. IL strategies can take advantage of the dual nature (discrete ions) of ILs to realize enhancements which may include controlled solubility (e.g., both hydrophilic and hydrophobic ILs are possible), bioavailability or bioactivity, stability, elimination of polymorphism, new delivery options (e.g., slow release or the IL-API as ‘solvent’), or even customized pharmaceutical cocktails. Here we exemplify this approach with, among others, lidocaine docusate (LD), a hydrophobic room temperature IL which, when compared to lidocaine hydrochloride, exhibits modified solubility, increased thermal stability, and a significant enhancement in the efficacy of topical analgesia in two different models of mouse antinociception. Studies of the suppression of nerve growth factor mediated neuronal differentiation in rat pheochromocytoma (PC12) cells suggests potential differences between LD and lidocaine hydrochloride at the cellular level indicating an entirely different mechanism of action. Taken together these results suggest that the unique physiochemical properties of ILs in general, may confer a novel effect for the bioactivity of an API due to (at least) slow-release properties in addition to novel delivery mechanisms.
755 citations
Journal Article•
TL;DR: In this article, the authors propose a method for measuring the performance of a single node in a set of images.ING and INDEXING, e.g., this article.
490 citations
Book•
26 Aug 2009
TL;DR: The literature on solubility data for pharmaceuticals has changed in recent years from being mainly concerned with liquid chromatography to gas chromatography and now also includes “solid-phase” data.
Abstract: Handbook of solubility data for pharmaceuticals , Handbook of solubility data for pharmaceuticals , کتابخانه دیجیتال جندی شاپور اهواز
477 citations