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Flor Tecson-Tumang

Bio: Flor Tecson-Tumang is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Drug resistance & Endocarditis. The author has an hindex of 3, co-authored 3 publications receiving 124 citations.

Papers
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Journal ArticleDOI
TL;DR: Oral bacitracin may be an effective alternative to commercially available oral vancomycin for the eradication of VREF from the enteric tract and may contribute to its nosocomial spread.

75 citations

Journal ArticleDOI
TL;DR: During the first twelve months after ciprofloxacin was introduced for clinical use at this institution, 65 new patients were found to be either infected or colonized by methicillin-resistant Staphylococcus aureus (MRSA) which were also cIProfl oxacin resistant (CR-MRSA).
Abstract: During the first twelve months after ciprofloxacin was introduced for clinical use at our institution, 65 new patients were found to be either infected or colonized by methicillin-resistant Staphylococcus aureus (MRSA) which were also ciprofloxacin resistant (CR-MRSA). Only 18 of these patients (28%) had been previously exposed to this antibiotic. Nine (50%) of the 18 patients had received ciprofloxacin for treatment for a pathogen other than MRSA. Although the initial cases of colonization or infection with CR-MRSA can be directly related to ciprofloxacin use, many of the subsequent cases of colonization and infection were not the consequence of ciprofloxacin therapy but rather hospital transmission of existing CR-MRSA.

44 citations

Journal ArticleDOI
TL;DR: A mathematical model based upon Fick's second law of diffusion was developed and solved on a PDP-II computer and can be used to estimate antibiotic levels in different areas of a valvular vegetation.
Abstract: The effect of vegetation size upon the concentration of antibiotic within various points of a fibrin-clot heart valve vegetation such as ones found in bacterial endocarditis was examined. A mathematic

6 citations


Cited by
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Journal ArticleDOI
TL;DR: Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections, however, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became resistant to many of the first effective drugs.
Abstract: Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became resistant to many of the first effective drugs. For example, the development of resistance to penicillin in Staphylococcus aureus by the production of a β-lactamase quickly decreased the usefulness of penicillin for serious staphylococcal infections, especially among hospitalized patients, in whom resistant strains are frequently found before they spread to the community.1 Initially, the problem of bacterial resistance to antimicrobial drugs was solved by the discovery of . . .

1,099 citations

Journal ArticleDOI
TL;DR: This work reviews VRE, including their history, mechanisms of resistance, epidemiology, control measures, and treatment, and raises significant concerns about the emergence of vancomycin-resistant Staphylococcus aureus.
Abstract: After they were first identified in the mid-1980s, vancomycin-resistant enterococci (VRE) spread rapidly and became a major problem in many institutions both in Europe and the United States. Since VRE have intrinsic resistance to most of the commonly used antibiotics and the ability to acquire resistance to most of the current available antibiotics, either by mutation or by receipt of foreign genetic material, they have a selective advantage over other microorganisms in the intestinal flora and pose a major therapeutic challenge. The possibility of transfer of vancomycin resistance genes to other gram-positive organisms raises significant concerns about the emergence of vancomycin-resistant Staphylococcus aureus. We review VRE, including their history, mechanisms of resistance, epidemiology, control measures, and treatment.

878 citations

Journal ArticleDOI
TL;DR: The emergence of enterococci with resistance to vancomycin, seen predominantly in the species E. faecium, has been followed by an increase in the frequency with which this species is recovered.
Abstract: Enterococci are best known as antibiotic-resistant opportunistic pathogens that are commonly recovered from patients who have received multiple courses of antibiotics and have been hospitalized for prolonged periods.1–6 These organisms were well established as a cause of endocarditis and urinary tract infections by the early 1900s,3 and members of the species Enterococcus faecalis were known to be a common cause of nosocomial infections by the early 1980s.3,7–9 The emergence of enterococci with resistance to vancomycin, seen predominantly in the species E. faecium, has been followed by an increase in the frequency with which this species is recovered. . . .

851 citations

Journal ArticleDOI
TL;DR: In order to obtain pan-European data on methicillin-resistantStaphylococcus aureus (MRSA), 43 laboratories from 10 European countries each screened 200 consecutive Staphyloccus Aureus isolates for MRSA resistance only one isolate per patient was permitted All participants used a uniform oxacillin-supplemented screening plate and sent to Munich for reconfirmation and further susceptibility testing as mentioned in this paper.
Abstract: In order to obtain pan-European data on methicillin-resistantStaphylococcus aureus (MRSA), 43 laboratories from ten European countries each screened 200 consecutiveStaphylococcus aureus isolates for methicillin resistance Only one isolate per patient was permitted All participants used a uniform oxacillin-supplemented screening plate MRSA isolates were sent to Munich for reconfirmation and further susceptibility testing Phage typing of the MRSA strains was performed in Denmark Of the 7,333Staphylococcus aureus strains screened, 936 (128%) were methicillin resistant The proportion of MRSA in the various European countries ranged from 30% in Spain, France and Italy Rates of resistance to the non-glycopeptide antibiotics were lowest for rifampin and highest for ciprofloxacin Sixty percent of the methicillin-resistant strains originated from patients in surgical and medical departments, with wounds being the most common isolation source MRSA was found more frequently in intensive care patients Only 13% of the strains were non-typable, and 76% of the isolates belonged to phage group III For each area phage typing detected one or a few dominating (epidemic) types, but 46% of the strains did not belong to these types; the MRSA population is thus a mixture of epidemic and non-epidemic strains MRSA seems to be a growing problem, especially in southern Europe, where incidence and rates of antibiotic resistance are alarmingly high

737 citations