Florence Levenez

TL;DR: It is found that primary resistance to ICIs can be attributed to abnormal gut microbiome composition, and Antibiotics inhibited the clinical benefit of ICIs in patients with advanced cancer.

TL;DR: It is shown how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals and suggested that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.

TL;DR: A. muciniphila is associated with a healthier metabolic status and better clinical outcomes after CR in overweight/obese adults, and the interaction between gut microbiota ecology and A. muc iniphila warrants further investigation.

TL;DR: In this paper, the authors evaluated the association between faecal A. muciniphila abundance and microbial gene richness after calorie restriction (CR) in overweight and obese adults.

TL;DR: Major gut microbiota alterations in severe Obesity are identified, which include decreased MGR and related functional pathways linked with metabolic deteriorations, which calls for additional strategies to improve the gut microbiota ecosystem and microbiome–host interactions in severe obesity.