F
Florence Monville
Researcher at French Institute of Health and Medical Research
Publications - 25
Citations - 8042
Florence Monville is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Breast cancer & Stem cell. The author has an hindex of 17, co-authored 20 publications receiving 7547 citations. Previous affiliations of Florence Monville include Aix-Marseille University.
Papers
More filters
Journal ArticleDOI
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
Christophe Ginestier,Min Hee Hur,Emmanuelle Charafe-Jauffret,Florence Monville,Julie Dutcher,Marty Brown,Jocelyne Jacquemier,Patrice Viens,Celina G. Kleer,Suling Liu,Anne F. Schott,Daniel F. Hayes,Daniel Birnbaum,Max S. Wicha,Gabriela Dontu +14 more
TL;DR: It is shown that normal and cancer human mammary epithelial cells with increased aldehyde dehydrogenase activity (ALDH) have stem/progenitor properties and these cells contain the subpopulation of normal breast epithelium with the broadest lineage differentiation potential and greatest growth capacity in a xenotransplant model.
Journal ArticleDOI
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.
Emmanuelle Charafe-Jauffret,Christophe Ginestier,Flora Iovino,Julien Wicinski,Nathalie Cervera,Pascal Finetti,Min-Hee Hur,Mark E. Diebel,Florence Monville,Julie Dutcher,Marthy Brown,Patrice Viens,Luc Xerri,François Bertucci,Giorgio Stassi,Gabriela Dontu,Daniel Birnbaum,Max S. Wicha +17 more
TL;DR: It is shown that ALDEFLUOR-positive cells are responsible for mediating metastasis and the hierarchical organization of immortalized cell lines, establish techniques that can facilitate the characterization of regulatory pathways of CSCs, and identify potential stem cell markers and therapeutic targets.
Journal ArticleDOI
Gene expression profiling of breast cell lines identifies potential new basal markers
E Charafe-Jauffret,Christophe Ginestier,Florence Monville,Pascal Finetti,José Adélaïde,Nathalie Cervera,S Fekairi,Luc Xerri,Jocelyne Jacquemier,David Jérémie Birnbaum,François Bertucci +10 more
TL;DR: The BCL basal/luminal signature correctly re-classified the published series of tumour samples that originally served to identify the molecular subtypes, suggesting that the identified markers should be useful for tumour classification and might represent promising targets for disease management.
Journal ArticleDOI
Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks
Suling Liu,Christophe Ginestier,Sing J. Ou,Shawn G. Clouthier,Shivani H. Patel,Florence Monville,Hasan Korkaya,Amber Heath,Julie Dutcher,Celina G. Kleer,Younghun Jung,Gabriela Dontu,Russell S. Taichman,Max S. Wicha +13 more
TL;DR: Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population through cytokine loops involving IL6 and CXCL7.