Florian Marks

TL;DR: This study provides the first comprehensive assessment of the global burden of AMR, as well as an evaluation of the availability of data, and estimates aggregated to the global and regional level.

TL;DR: In this paper, a comprehensive post-efficacy strategy for the next steps to ensure vaccination of the global population is now required, including how to manufacture billions of doses of high-quality vaccines, support for vaccine purchase, coordination of supply, equitable distribution of vaccines and the logistics of global vaccine delivery, all of which are a prelude to a massive vaccination campaign targeting people of all ages.

TL;DR: Although improvements in water and sanitation remain essential, increased vaccine use and improved data and surveillance to inform vaccine rollout are likely to drive the greatest improvements in the global burden of the disease.

TL;DR: This whole-genome sequence analysis of Salmonella enterica serovar Typhi identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years, and identifies numerous transmissions of H58.

TL;DR: The development of iNTS vaccines and the introduction of S Typhi conjugate vaccines should be considered for high-incidence settings, such as those identified in this study.