Foster C. Gonsalves

TL;DR: In this paper, an RNAi-based modifier screening strategy was used to identify Wnt/β-catenin-induced target genes and phenotypes in various mammalian and cancer cell lines.

TL;DR: The LXR/ApoE axis is implicate in the regulation of innate immune suppression and as a target for enhancing the efficacy of cancer immunotherapy in patients through genetic and pharmacological approaches.

TL;DR: It is concluded that the N- and C- termini function unexpectedly in negatively regulating Stat 92E activity, possibly by decreasing dimer dephosphorylation or increasing stability of DNA interaction, and that Stat92E(R442) has a nuclear function by altering dimer:DNA binding.

TL;DR: This study re-assess the previously published transcriptional reporter-based whole-genome RNAi screens for the Wingless and Hedgehog signaling pathways using second generation double-stranded RNA libraries and investigates other factors that may influence the outcome of such screens, including cell-type specificity, robustness of reporters, and assay normalization.

TL;DR: Blocking β-catenin/TCF1–mediated transcriptional activation with a specific small molecule or by TCF1 knockdown delays the mouse embryonic stem cell differentiation program and enhances pluripotency.