Franca Marino

TL;DR: It is shown that in human Tregs endogenous catecholamines subserve an autocrine/paracrine loop involving dopaminergic pathways and resulting in down-regulation of Treg function, which occurs without affecting the production of tumor necrosis factor-alpha or interferon-gamma.

TL;DR: A systematic review of the literature showed that neutrophils were independent predictors of cardiovascular outcomes when analysed concomitantly with other markers of inflammation (WBC, CRP), highlighting the potential application of this inexpensive and readily available inflammatory marker for risk stratification in patients with ACS and/or cardiac revascularisation.

TL;DR: A low but significant increase in the number of CD4+ T cells with phenotype and functional features of Treg cells in LC patients compared to normal healthy controls (NHC) was found, and the lack of correlation between cancer stage and the number or the function of peripheral T Reg cells inLC patients refuted the hypothesis that these cells are involved in tumor spreading.

TL;DR: The complex phenotypic and functional profile of CD4+ T cell subsets in PD patients strengthen the evidence that peripheral adaptive immunity is involved in PD, and represents a target for the preclinical and clinical assessment of novel immunomodulating therapeutics.

TL;DR: The present review addresses emerging issues in the adrenergic modulation of immune cells, including the specific pattern of adrenoceptor expression on immune cells and their role and changes upon cell differentiation and activation.