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Frances Humby
Researcher at Queen Mary University of London
Publications - 85
Citations - 3443
Frances Humby is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Rheumatoid arthritis & Synovitis. The author has an hindex of 23, co-authored 76 publications receiving 2471 citations. Previous affiliations of Frances Humby include Barts Health NHS Trust & University of London.
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Journal ArticleDOI
Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
Frances Humby,Michele Bombardieri,Antonio Manzo,Stephen Kelly,Mark Blades,Bruce Kirkham,Jo Spencer,Costantino Pitzalis +7 more
TL;DR: It is demonstrated that FDC+ follicular units invariably express AID and are surrounded by ACPA-producing plasma cells, providing strong evidence that ectopic lymphoid structures in the RA synovium are functional and support autoantibody production.
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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring.
Valentina Pucino,Valentina Pucino,Michelangelo Certo,Michelangelo Certo,Vinay Bulusu,Danilo Cucchi,Katriona Goldmann,Elena Pontarini,Robert Haas,Joanne Smith,Sarah E. Headland,K. Blighe,Massimiliano Ruscica,Frances Humby,Myles Lewis,Jurre J. Kamphorst,Michele Bombardieri,Costantino Pitzalis,Claudio Mauro +18 more
TL;DR: It is proposed that lactate/SLC5A12-induced metabolic reprogramming is a distinctive feature of lymphoid synovitis in rheumatoid arthritis patients and a potential therapeutic target in chronic inflammatory disorders.
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Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis and MALT Lymphoma in Sjögren’s Syndrome
Michele Bombardieri,Francesca Barone,Frances Humby,Stephen Kelly,Mark McGurk,Peter Morgan,Stephen Challacombe,Salvatore De Vita,Guido Valesini,Jo Spencer,Costantino Pitzalis +10 more
TL;DR: It is reported that AID retains its exclusive association with numerous, residual GCs in parotid SS-MALT lymphomas, whereas neoplastic marginal zone-like B cells are consistently AID negative, which strongly support the notion that ectopic lymphoid structures in SS-SGs express the molecular machinery to support local autoantibody production and B cell expansion and may play a crucial role toward lymphomagenesis.
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EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis
Hanna W. van Steenbergen,Daniel Aletaha,Liesbeth J J Beaart-van de Voorde,Elisabeth Brouwer,Catalin Codreanu,Bernard Combe,João Eurico Fonseca,Merete Lund Hetland,Frances Humby,Tore K Kvien,Karin Niedermann,Laura Nuño,Sue Oliver,Solbritt Rantapää-Dahlqvist,Karim Raza,Dirkjan van Schaardenburg,Georg Schett,Liesbeth De Smet,Gabriella Szücs,Jirí Vencovský,Piotr Wiland,Maarten de Wit,Robert Landewé,Annette H M van der Helm-van Mil +23 more
TL;DR: A set of clinical characteristics for patients with arthralgia who are at risk of progression to RA was established by experts based on their clinical experience.
Journal ArticleDOI
Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes
Myles Lewis,Michael R. Barnes,Michael R. Barnes,K. Blighe,Katriona Goldmann,Sharmila Rana,Jason A. Hackney,Nandhini Ramamoorthi,Christopher R. John,David Watson,David Watson,David Watson,Sarah K. Kummerfeld,Rebecca Hands,Sudeh Riahi,Vidalba Rocher-Ros,Felice Rivellese,Frances Humby,Stephen Kelly,Michele Bombardieri,Nora Ng,M DiCicco,Désirée van der Heijde,Robert Landewé,Annette H M van der Helm-van Mil,Alberto Cauli,Iain B. McInnes,Christopher D. Buckley,Christopher D. Buckley,Ernest Choy,Peter C. Taylor,Michael J. Townsend,Costantino Pitzalis +32 more
TL;DR: In this paper, a comprehensive RNA sequencing analysis of the molecular pathways that drive early RA progression in the disease tissue (synovium), comparing matched peripheral blood RNA-seq in a large cohort of early treatment-naive patients, namely, the Pathobiology of Early Arthritis Cohort (PEAC).