F
Francesca Sisto
Researcher at University of Milan
Publications - 67
Citations - 2243
Francesca Sisto is an academic researcher from University of Milan. The author has contributed to research in topics: Mesenchymal stem cell & Stromal cell. The author has an hindex of 21, co-authored 62 publications receiving 1684 citations. Previous affiliations of Francesca Sisto include Sapienza University of Rome.
Papers
More filters
Journal ArticleDOI
Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery.
Luisa Pascucci,Valentina Coccè,Arianna Bonomi,Diletta Ami,Piero Ceccarelli,Emilio Ciusani,Lucia Viganò,Alberta Locatelli,Francesca Sisto,Silvia Maria Doglia,Eugenio Parati,Maria Ester Bernardo,Maurizio Muraca,Giulio Alessandri,Gianpietro Bondiolotti,Augusto Pessina +15 more
TL;DR: This work has found that MSCs can acquire strong anti-tumor activity after priming with Paclitaxel (PTX) through their capacity to uptake and then release the drug, suggesting the possibility of using M SCs as a factory to develop drugs with a higher cell-target specificity.
Journal ArticleDOI
Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy
Augusto Pessina,Arianna Bonomi,Valentina Coccè,Gloria Invernici,Stefania Elena Navone,Loredana Cavicchini,Francesca Sisto,Maura Ferrari,Lucia Viganò,Alberta Locatelli,Emilio Ciusani,Graziella Cappelletti,Daniele Cartelli,Caruso Arnaldo,Eugenio Parati,Giovanni Marfia,Roberto Pallini,Maria Laura Falchetti,Giulio Alessandri +18 more
TL;DR: These data demonstrate, for the first time, that without any genetic manipulation, mesenchymal stromal cells can uptake and subsequently slowly release PTX, which may lead to potential new tools to increase efficacy of cancer therapy.
Journal ArticleDOI
Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides.
Franco Chimenti,Bruna Bizzarri,Adriana Bolasco,Daniela Secci,Paola Chimenti,Arianna Granese,Simone Carradori,Daniela Rivanera,Alessandra Zicari,M.M. Scaltrito,Francesca Sisto +10 more
TL;DR: N-substituted-3-carboxamido-coumarin derivatives were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clinical strains, including five metronidazole resistant ones.
Journal ArticleDOI
Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study.
Gokhan Zengin,Luigi Menghini,Antonella Di Sotto,Romina Mancinelli,Francesca Sisto,Simone Carradori,Stefania Cesa,Caterina Fraschetti,Antonello Filippi,Letizia Angiolella,Marcello Locatelli,Luisa Mannina,Cinzia Ingallina,Valentina Puca,Marianna D’Antonio,Rossella Grande +15 more
TL;DR: The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.
Journal ArticleDOI
Mesenchymal stromal cells primed with Paclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice.
Augusto Pessina,Valentina Coccè,Luisa Pascucci,Arianna Bonomi,Loredana Cavicchini,Francesca Sisto,Maura Ferrari,Emilio Ciusani,Antonio Crovace,Maria Laura Falchetti,Sonia Zicari,Arnaldo Caruso,Stefania Elena Navone,Giovanni Marfia,Anna Benetti,Piero Ceccarelli,Eugenio Parati,Giulio Alessandri +17 more
TL;DR: It is shown that MSCs loaded with Paclitaxel (PTX) acquire a potent anti‐tumour activity and priming hMSCs with PTX is a simple procedure that does not require any genetic cell manipulation.