F
Francesca Torti
Researcher at University of Milan
Publications - 25
Citations - 7208
Francesca Torti is an academic researcher from University of Milan. The author has contributed to research in topics: Robust regression & Outlier. The author has an hindex of 12, co-authored 21 publications receiving 5495 citations. Previous affiliations of Francesca Torti include European Institute of Oncology & Max Delbrück Center for Molecular Medicine.
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Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
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Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals
Andranik Ivanov,Sebastian Memczak,Emanuel Wyler,Francesca Torti,Hagit T. Porath,Marta Rodriguez Orejuela,Michael Piechotta,Erez Y. Levanon,Markus Landthaler,Christoph Dieterich,Nikolaus Rajewsky +10 more
TL;DR: The data support a model of animal circRNA biogenesis in which competing RNA-RNA interactions of introns form larger structures that promote circularization of embedded exons, whereas ADAR1 antagonizes circRNA expression by melting stems within these interactions.
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RHOA-FAK Is a Required Signaling Axis for the Maintenance of KRAS-Driven Lung Adenocarcinomas
Georgia Konstantinidou,Giorgio Ramadori,Francesca Torti,Kim Kangasniemi,Rachel E. Ramirez,Yiran Cai,Carmen Behrens,Michael T. Dellinger,Rolf A. Brekken,Ignacio I. Wistuba,Adriana Heguy,Julie Teruya-Feldstein,Pier Paolo Scaglioni +12 more
TL;DR: It is reported that FAK inhibitors exert potent antitumor effects in NSCLCs that express mutant KRAS in association with INK4A/ARF deficiency, revealing a novel genotype-specific vulnerability of cancer cells that can be exploited for therapeutic purposes.
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FSDA: A MATLAB toolbox for robust analysis and interactive data exploration
TL;DR: The potential of the FSDA in chemometrics using data from chemical and pharmaceutical problems, where the presence of outliers, multiple groups, deviations from normality and other complex structures is not an exceptional circumstance is shown.
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Global characterization of the oocyte-to-embryo transition in Caenorhabditis elegans uncovers a novel mRNA clearance mechanism
Marlon Stoeckius,Dominic Grün,Marieluise Kirchner,Salah Ayoub,Francesca Torti,Fabio Piano,Margareta Herzog,Matthias Selbach,Nikolaus Rajewsky +8 more
TL;DR: Analysis of transcriptome‐wide, expression of mRNAs and thousands of proteins in Caenorhabditis elegans oocytes, 1‐cell, and 2‐cell embryos represents a first comprehensive gene expression atlas during the OET in animals and suggests a mechanism in which the polyC motif and binding partners direct degradation of maternal m RNAs.