Francesco Lozupone

TL;DR: The results suggest that the Exotest for detection of plasma exosomes carrying tumor-associated antigens may represent a novel tool for clinical management of cancer patients.

TL;DR: The data provide evidence for a novel mechanism potentially operating in Fas tumor counterattack through the secretion of subcellular particles expressing functional FasL, which may form a sort of front line hindering lymphocytes and other immunocompetent cells from entering neoplastic lesions and exert their antitumor activity.

TL;DR: The results open new possibilities for the treatment of drug-resistant tumors through combination strategies based on the use of well-tolerated pH modulators such as PPIs.

TL;DR: The proapoptotic activity of PPI was consistent with a clear inhibition of tumor growth following PPI treatment of B-cell lymphoma in severe combined immunodeficient mice, which further supports the importance of acidity and pH gradients in tumor cell homeostasis and suggests new therapeutic approaches based on PPI.

TL;DR: Preclinical evidence supporting the use of PPI as novel therapeutic strategy for melanoma is shown, providing the proof of concept that PPI target human melanoma modifying tumor pH gradients.