Francesco Raimondi

TL;DR: This work systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique Gα subunit C termini, and identified sequence-based coupling specificity features, inside and outside the transmembrane domain, which were used to develop a coupling predictor that outperforms previous methods.

TL;DR: The following new analysis modules have been added since the publication of the original Wordom paper in 2007: assignment of secondary structure, calculation of solvent accessible surfaces, elastic network model, motion cross correlations, protein structure network, shortest intra‐molecular and inter‐molescular communication paths, kinetic grouping analysis, and calculation of mincut‐based free energy profiles.

TL;DR: It is concluded that selected bile acids modulate intestinal permeability via EGF receptor autophosphorylation, occludin dephosphorylated, and rearrangement at the tight junction level and the effect is mediated by the src family kinases and is abolished by EGF treatment.

TL;DR: The results suggest a useful role for L. reuteri supplementation in improving feeding tolerance and gut function in formula-fed preterm newborns.

TL;DR: Thirty-one patients with visceral leishmaniasis (VL) caused by Leishmania infantum received liposomal amphotericin B (AmBisome) in a multi-centre study and were cured without significant adverse events and without relapse during 12-24 months of follow-up.