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Francesco Santoli

Bio: Francesco Santoli is an academic researcher from INAF. The author has contributed to research in topics: Accelerometer & Spacecraft. The author has an hindex of 8, co-authored 54 publications receiving 248 citations.


Papers
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Journal ArticleDOI
TL;DR: The Italian Spring Accelerometer (ISA) as mentioned in this paper is a three-axis accelerometer devoted to the measurement of non-gravitational perturbations acting on the Mercury Planetary Orbiter (MPO), whose knowledge is important in order to fully exploit the quality of the tracking data.

49 citations

Journal ArticleDOI
TL;DR: In this article , two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven individual cohorts.

48 citations

Journal ArticleDOI
Luca Baldini1, Luca Baldini2, M. Barbanera2, M. Barbanera1, Ronaldo Bellazzini2, R. Bonino3, R. Bonino2, Fabio Borotto2, Alessandro Brez2, Ciro Caporale2, Claudia Cardelli2, S. Castellano2, M. Ceccanti2, Saverio Citraro2, N. Di Lalla4, Luca Latronico2, Leonardo Lucchesi2, Carlo Magazzu2, Guido Magazzu2, S. Maldera2, Alberto Manfreda2, Marco Marengo2, Alessandra Marrocchesi2, Paolo Mereu2, Massimo Minuti2, Federico Mosti2, Hikmat Nasimi2, Hikmat Nasimi1, Alessio Nuti2, C. Oppedisano2, Leonardo Orsini2, Melissa Pesce-Rollins2, Michele Pinchera2, Alessandro Profeti2, Carmelo Sgrò2, Gloria Spandre2, Marcello Tardiola2, D. Zanetti2, Fabrizio Amici, Hans Andersson5, Primo Attina6, Matteo Bachetti6, Wayne H. Baumgartner7, Daniele Brienza, Rita Carpentiero8, Marco Castronuovo8, Luca Cavalli, E. Cavazzuti8, Mauro Centrone6, Enrico Costa, Elisa D'Alba, Fabio D'Amico8, E. Del Monte, S. Di Cosimo, A. Di Marco, G. Di Persio, I. Donnarumma8, Y. Evangelista, Sergio Fabiani, R. Ferrazzoli9, R. Ferrazzoli10, Takao Kitaguchi, F. La Monaca, Carlo Lefevre, Pasqualino Loffredo, Paolo Lorenzi, Elio Mangraviti, Giorgio Matt11, T. Meilahti5, Alfredo Morbidini, F. Muleri, Toshio Nakano, Barbara Negri8, S. Nenonen5, Steve O'Dell7, M. Perri6, Raffaele Piazzolla, S. Pieraccini, Maura Pilia6, Simonetta Puccetti8, Brian D. Ramsey7, John Rankin9, John Rankin10, Ajay Ratheesh10, Ajay Ratheesh9, A. Rubini, Francesco Santoli, Paolo Sarra, E. Scalise, Andrea Sciortino, P. Soffitta, Toru Tamagawa, Allyn F. Tennant7, Antonino Tobia, Alessio Trois6, K. Uchiyama, Marco Vimercati, Martin C. Weisskopf7, Fei Xie, Francesco Zanetti, Y. Zhou 
TL;DR: In this paper, the design, manufacturing, and test of the IXPE focal plane detectors are reviewed, with particular emphasis on the connection between the science drivers, the performance metrics and the operational aspects, and a thorough characterization of the GPDs in terms of effective noise, trigger efficiency, dead time, uniformity of response, and spectral and polarimetric performance.

39 citations

Journal ArticleDOI
TL;DR: In this paper, the authors describe the scientific goals of the Geodesy and Geophysics Working Group (GGWG) that aims at addressing fundamental questions regarding Mercury's internal structure and evolution.
Abstract: In preparation for the ESA/JAXA BepiColombo mission to Mercury, thematic working groups had been established for coordinating the activities within the BepiColombo Science Working Team in specific fields. Here we describe the scientific goals of the Geodesy and Geophysics Working Group (GGWG) that aims at addressing fundamental questions regarding Mercury’s internal structure and evolution. This multidisciplinary investigation will also test the gravity laws by using the planet Mercury as a proof mass. The instruments on the Mercury Planetary Orbiter (MPO), which are devoted to accomplishing the GGWG science objectives, include the BepiColombo Laser Altimeter (BELA), the Mercury orbiter radio science experiment (MORE), and the MPO magnetometer (MPO-MAG). The onboard Italian spring accelerometer (ISA) will greatly aid the orbit reconstruction needed by the gravity investigation and laser altimetry. We report the current knowledge on the geophysics, geodesy, and evolution of Mercury after the successful NASA mission MESSENGER and set the prospects for the BepiColombo science investigations based on the latest findings on Mercury’s interior. The MPO spacecraft of the BepiColombo mission will provide extremely accurate measurements of Mercury’s topography, gravity, and magnetic field, extending and improving MESSENGER data coverage, in particular in the southern hemisphere. Furthermore, the dual-spacecraft configuration of the BepiColombo mission with the Mio spacecraft at higher altitudes than the MPO spacecraft will be fundamental for decoupling the internal and external contributions of Mercury’s magnetic field. Thanks to the synergy between the geophysical instrument suite and to the complementary instruments dedicated to the investigations on Mercury’s surface, composition, and environment, the BepiColombo mission is poised to advance our understanding of the interior and evolution of the innermost planet of the solar system.

38 citations


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Journal Article
TL;DR: The first direct detection of gravitational waves and the first observation of a binary black hole merger were reported in this paper, with a false alarm rate estimated to be less than 1 event per 203,000 years, equivalent to a significance greater than 5.1σ.
Abstract: On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-Wave Observatory simultaneously observed a transient gravitational-wave signal. The signal sweeps upwards in frequency from 35 to 250 Hz with a peak gravitational-wave strain of 1.0×10(-21). It matches the waveform predicted by general relativity for the inspiral and merger of a pair of black holes and the ringdown of the resulting single black hole. The signal was observed with a matched-filter signal-to-noise ratio of 24 and a false alarm rate estimated to be less than 1 event per 203,000 years, equivalent to a significance greater than 5.1σ. The source lies at a luminosity distance of 410(-180)(+160) Mpc corresponding to a redshift z=0.09(-0.04)(+0.03). In the source frame, the initial black hole masses are 36(-4)(+5)M⊙ and 29(-4)(+4)M⊙, and the final black hole mass is 62(-4)(+4)M⊙, with 3.0(-0.5)(+0.5)M⊙c(2) radiated in gravitational waves. All uncertainties define 90% credible intervals. These observations demonstrate the existence of binary stellar-mass black hole systems. This is the first direct detection of gravitational waves and the first observation of a binary black hole merger.

4,375 citations

Journal Article
TL;DR: 1. Place animal in induction chamber and anesthetize the mouse and ensure sedation, move it to a nose cone for hair removal using cream and reduce anesthesia to maintain proper heart rate.
Abstract: 1. Place animal in induction chamber and anesthetize the mouse and ensure sedation. 2. Once the animal is sedated, move it to a nose cone for hair removal using cream. Only apply cream to the area of the chest that will be utilized for imaging. Once the hair is removed, wipe area with wet gauze to ensure all hair is removed. 3. Move the animal to the imaging platform and tape its paws to the ECG lead plates and insert rectal probe. Body temperature should be maintained at 36-37°C. During imaging, reduce anesthesia to maintain proper heart rate. If the animal shows signs of being awake, use a higher concentration of anesthetic.

1,557 citations

Journal ArticleDOI
TL;DR: BepiColombo as mentioned in this paper is an interdisciplinary mission to explore Mercury, the planet closest to the sun, carried out jointly between the European Space Agency and the Japanese Aerospace Exploration Agency.

429 citations

01 Jan 1996
TL;DR: In this paper, the authors used 24 years of laser ranging data to test the principle of equivalence, geodetic precession, the PPN parameters beta and gamma, and G/G.
Abstract: Analysis of 24 years of lunar laser ranging data is used to test the principle of equivalence, geodetic precession, the PPN parameters beta and gamma, and G/G. Recent data can be fitted with a rms scatter of 3 cm. (a) Using the Nordtvedt effect to test the principle of equivalence, it is found that the Moon and Earth accelerate alike in the Sun's field. The relative accelerations match to within 5 x 10(exp -13) . This limit, combined with an independent determination of y from planetary time delay, gives beta. Including the uncertainty due to compositional differences, the parameter beta differs from unity by no more than 0.0014; and, if the weak equivalence principle is satisfied, the difference is no more than 0.0006. (b) Geodetic precession matches its expected 19.2 marc sec/yr rate within 0.7%. This corresponds to a 1% test of gamma. (c) Apart from the Nordtvedt effect, beta and gamma can be tested from their influence on the lunar orbit. It is argued theoretically that the linear combination 0.8(beta) + 1.4(gamma) can be tested at the 1% level of accuracy. For solutions using numerically derived partial derivatives, higher sensitivity is found. Both 6 and y match the values of general relativity to within 0.005, and the linear combination beta+ gamma matches to within 0,003, but caution is advised due to the lack of theoretical understanding of these sensitivities. (d) No evidence for a changing gravitational constant is found, with absolute value of G/G less than or equal to 8 x lO(exp -12)/yr. There is significant sensitivity to G/G through solar perturbations on the lunar orbit.

255 citations

01 Jul 2007
TL;DR: Observations of radar speckle patterns tied to the rotation of Mercury establish that the planet occupies a Cassini state with obliquity of 2.11 ± 0.1 arc minutes, and indicate that the mantle of Mercury is decoupled from a core that is at least partially molten.
Abstract: Observations of radar speckle patterns tied to the rotation of Mercury establish that the planet occupies a Cassini state with obliquity of 2.11 ± 0.1 arc minutes. The measurements show that the planet exhibits librations in longitude that are forced at the 88-day orbital period, as predicted by theory. The large amplitude of the oscillations, 35.8 ± 2 arc seconds, together with the Mariner 10 determination of the gravitational harmonic coefficient C22, indicates that the mantle of Mercury is decoupled from a core that is at least partially molten.

255 citations