F
Francesco Tedesco
Researcher at University College London
Publications - 258
Citations - 14021
Francesco Tedesco is an academic researcher from University College London. The author has contributed to research in topics: Complement system & Endothelial stem cell. The author has an hindex of 61, co-authored 245 publications receiving 12276 citations. Previous affiliations of Francesco Tedesco include UCL Institute of Child Health & Sapienza University of Rome.
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Journal ArticleDOI
Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis
Josée Golay,Luisella Zaffaroni,Thomas Vaccari,Thomas Vaccari,Manuela Lazzari,Manuela Lazzari,Gian Maria Borleri,Gian Maria Borleri,Sergio Bernasconi,Sergio Bernasconi,Francesco Tedesco,Francesco Tedesco,Alessandro Rambaldi,Alessandro Rambaldi,Martino Introna,Martino Introna +15 more
TL;DR: It is concluded that CDC and ADCC are major mechanisms of action of rituximab on B-cell lymphomas and that a heterogeneous susceptibility of different lymphoma cells to complement may be at least in part responsible for the heterogeneity of the response of different patients to ritUXimab in vivo.
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Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells
TL;DR: The main properties of satellite cells and other myogenic progenitors are discussed as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy.
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Pathogenesis of antiphospholipid syndrome: understanding the antibodies
TL;DR: Characterization of the molecular basis of the pathogenic mechanisms involved, including the putative second hits and the role of complement activation, might offer an answer to this question.
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Multimer Formation and Ligand Recognition by the Long Pentraxin PTX3 SIMILARITIES AND DIFFERENCES WITH THE SHORT PENTRAXINS C-REACTIVE PROTEIN AND SERUM AMYLOID P COMPONENT
Barbara Bottazzi,Valérie Vouret-Craviari,Antonio Bastone,Luca De Gioia,Cristian Matteucci,Giuseppe Peri,Fabio Spreafico,M. Pausa,Cinzia D'Ettorre,Elisabetta Gianazza,Aldo Tagliabue,Mario Salmona,Francesco Tedesco,Martino Introna,Alberto Mantovani,Alberto Mantovani +15 more
TL;DR: The capacity to bind C1q, mediated by the pentraxin domain, is consistent with the view that PTX3, produced in tissues by endothelial cells or macrophages in response to interleukin-1 and tumor necrosis factor, may act as a local regulator of innate immunity.
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Collagen VI regulates satellite cell self-renewal and muscle regeneration
Anna Urciuolo,Marco Quarta,Valeria Morbidoni,Francesca Gattazzo,Sibilla Molon,Paolo Grumati,Francesca Montemurro,Francesco Tedesco,Bert Blaauw,Giulio Cossu,Giovanni Vozzi,Thomas A. Rando,Paolo Bonaldo +12 more
TL;DR: It is shown that the extracellular matrix protein collagen VI is a key component of the satellite cell niche and establishes a critical role for an extracllular matrix molecule in satellite cell self-renewal and open new venues for therapies of collagen VI-related muscle diseases.