F
Francis Frankenne
Researcher at University of Liège
Publications - 120
Citations - 6066
Francis Frankenne is an academic researcher from University of Liège. The author has contributed to research in topics: Matrix metalloproteinase & Placenta. The author has an hindex of 41, co-authored 120 publications receiving 5858 citations. Previous affiliations of Francis Frankenne include Umeå University & Université libre de Bruxelles.
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Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: Pathophysiological consequences
Vassilis Tsatsaris,Frédéric Goffin,Carine Munaut,Jean-François Brichant,Marie-Rose Pignon,Agnès Noël,Jean-Pierre Schaaps,Dominique Cabrol,Francis Frankenne,Jean-Michel Foidart +9 more
TL;DR: Two different pathophysiological mechanisms associated with preeclampsia are suggested, related to an overproduction of competitive soluble VEGFR-1 that may lead to suppression of VEGF-A and PlGF effects and the down-regulation of its membrane bound form in the placental bed, which may result in the defective uteroplacental development.
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The Physiology of Growth Hormones (Ghs) in Pregnant Women and Partial Characterization of the Placental Gh Variant
TL;DR: Pure PGH, obtained in small quantities by preparative electrophoresis, was found to bind to hepatic GH receptor with an apparent high potency compared to that of pituitary GH, thus, PGH should act in vivo as a GH agonist sharing most of its biological properties.
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MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression
Nor Eddine Sounni,Laetitia Devy,Amin Hajitou,Francis Frankenne,Carine Munaut,Christine Gilles,Christophe Deroanne,Erik W. Thompson,Jean-Michel Foidart,Agnès Noël +9 more
TL;DR: The results emphasize the importance of MT1‐MMP during tumor angiogenesis and open new opportunities for the development of anti‐angiogenic strategies combining inhibitors ofMT1-MMP and VEGF antagonists.
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MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease.
Didier Cataldo,Carine Munaut,Agnès Noël,Francis Frankenne,Pierre Bartsch,Jean-Michel Foidart,Renaud Louis +6 more
TL;DR: Asthmatics and COPD patients display an increased gelatinolytic activity linked to M MP-2 and MMP-9 and higher levels of TIMP-1 in their sputum.
Journal ArticleDOI
Placental growth hormone levels in normal pregnancy and in pregnancies with intrauterine growth retardation.
V. Mirlesse,Francis Frankenne,E. Alsat,Micheline Poncelet,Georges Hennen,Danièle Evain-Brion +5 more
TL;DR: A relationship between placental GH levels in the maternal plasma and the development of the fetoplacental unit is suggested by means of two RIA and Plasma IGF-I levels were lower than normal.