Francis L. McCabe

TL;DR: Results suggest a novel tumor angiogenesis mechanism in which tumor-associated EMMPRIN functionally mediates tumor-stroma interactions and directly contributes to tumorAngiogenesis and growth by stimulating VEGF and MMP expression.

TL;DR: Comparison of the purified topoisomerase II from amsacrine-resistant P388 with that from amSacrine-sensitive P388 demonstrated that each cell type contained both p180 and p170; however, the relative amounts of the two proteins were consistently different in the two cell types.

TL;DR: The results of these in vivo and in vitro experiments suggest that the contrasting pharmacological profile of [Au(DPPE)2]Cl with respect to other gold(I) phosphine complexes may be related to both the kinetic stability of the complex and its stability in the presence of thiols.

TL;DR: There was no detectable correlation between tumorigenicity and metastatic potential, doubling time in vitro, production of tumor‐associated markers, xenograft histology or expression of specific oncogenes.

TL;DR: This work investigated the mechanism of resistance by murine P388 leukemia to camptothecin (topoisomerase I inhibitor) or amsacrine (topsomerase II inhibitor) and found that the resistant cells contained reduced levels of topoisomersase activity and messenger RNA.