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Francis M. Schleppnik

Bio: Francis M. Schleppnik is an academic researcher from Monsanto. The author has contributed to research in topics: Trifluoromethyl & Carbon-13 NMR. The author has an hindex of 2, co-authored 3 publications receiving 79 citations.

Papers
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Journal ArticleDOI
TL;DR: In this paper, a variety of 2-halo-5-thiazolecarboxylates was prepared from substituted 3-aminoacrylates and 3-ketoes-ters.

43 citations

Journal ArticleDOI
TL;DR: In this paper, the reaction of ethyl 4,4,4 trifluoroacetoacetate with methylhydrazine produced not only the previously reported 5-hydroxy-3-(trifluoromethyl)pyrazole 1 but also its unknown isomer the 3-hydrox-5-(trifioromethemyl) pyrazole 4.

39 citations

Journal ArticleDOI
TL;DR: In this article, the reaction of ethyl 4,4,4 trifluoroacetoacetate with methylhydrazine produced not only the previously reported 5-hydroxy-3-(trifluoromethyl)pyrazole 1 but also its unknown isomer the 3-hydrox-5-(trifioromethsyl) pyrazole 4. The structure assignements were established based on 13 C NMR spectra.
Abstract: Reaction of ethyl 4,4,4-trifluoroacetoacetate with methylhydrazine produced not only the previously reported 5-hydroxy-3-(trifluoromethyl)pyrazole 1 but also its unknown isomer the 3-hydroxy-5-(trifluoromethyl)pyrazole 4. The structure assignements are etablished based on 13 C NMR spectra. Compound 1 was converted to 5-chloro-3-(trifluoromethyl)pyrazolecarboxylic acid 3 in two steps.

Cited by
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Journal ArticleDOI
TL;DR: All compounds of the series have been screened for their antibacterial and antifungal activity studies and Structures of the products have been determined by chemical reactions and spectral studies.

207 citations

Book ChapterDOI
01 Jan 1996

103 citations

Journal ArticleDOI
Hong Dai1, Yongqiang Li1, Ding Du1, Xue Qin1, Xin Zhang1, Haibo Yu1, Jianxin Fang1 
TL;DR: A series of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety were synthesized and showed low acaricidal activity against Tetranychus cinnabarinus, while some title compounds displayed fungicidal and plant growth regulatory activities.
Abstract: A series of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety were synthesized. Their structures were confirmed by (1)H NMR, (13)C NMR, and elemental analysis. The preliminary bioassays showed that all of the title compounds had low acaricidal activity against Tetranychus cinnabarinus . However, most of them exhibited excellent insecticidal activity against Aphis medicagini at the dosage of 0.5 mg/mL, and some compounds still showed good insecticidal activity against A. medicagini even at the dosage of 0.2 mg/mL. Meanwhile, some title compounds displayed fungicidal and plant growth regulatory activities.

86 citations

Book ChapterDOI
TL;DR: In this paper, the chemistry of five-membered ring fluorinated heterocycles is discussed and two fundamentally different strategies by which fluorine and perfluoroalkyl groups can be introduced into target molecules.
Abstract: Publisher Summary This chapter deals with the chemistry of five-membered ring fluorinated heterocycles. Fluorine and perfluoroalkyl groups positioned strategically in target molecules can considerably modify the chemical properties, biological activity, and selectivity. Fluoro-containing compounds play a significant role in medicinal and agricultural chemistry, as well as in material science. A number of fluoro and perfluoroalkyl-substituted pharmaceuticals, agrochemicals, dyes, and polymers are largely commercialized. Important differences in chemical reactivity of fluorinated compounds are based on the difference in: (1) carbon–fluorine, (2) carbon–hydrogen bond energy, and (3) electronegativity between fluorine and hydrogen. It is observed that fluorine introduced into biologically active molecules can block metabolism. There are two fundamentally different strategies, by which fluorine and perfluoroalkyl groups can be introduced into target molecules: (1) direct introduction that occurs by direct substitution of hydrogen by fluorine and perfluoroalkyl groups in a late step of the reaction sequence, and (2) introduction of fluorine and perfluoroalkyl groups by the application of fluorine-containing building blocks, derived from the readily available starting materials.

80 citations